Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Tiazac Generic Name & Formulations
Legal Class
Rx
General Description
Diltiazem HCl 120mg, 180mg, 240mg, 300mg, 360mg, 420mg; ext-rel beads in caps.
Pharmacological Class
Calcium channel blocker (CCB) (benzothiazepine).
How Supplied
Caps—30, 90, 1000
Manufacturer
Generic Availability
YES
Mechanism of Action
The therapeutic effects of diltiazem HCl are believed to be related to its ability to
inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. Diltiazem HCl has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal workloads.
Tiazac Indications
Indications
Chronic stable angina.
Tiazac Dosage and Administration
Adult
May sprinkle contents on applesauce; do not crush or chew contents. Initially 120–180mg once daily; adjust at 1–2 week intervals; usual max 540mg/day.
Children
Not established.
Tiazac Contraindications
Contraindications
Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Severe hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.
Tiazac Boxed Warnings
Not Applicable
Tiazac Warnings/Precautions
Warnings/Precautions
Heart failure. Hypotension. Impaired renal or hepatic function. Monitor liver function. Discontinue if persistent rash occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Tiazac Pharmacokinetics
Elimination
Renal. Half-life: ~3–4.5hrs.
Tiazac Interactions
Interactions
Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, ivabradine (avoid), simvastatin (limit simvastatin dose to 10mg/day), quinidine; consider dose adjustments; monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.
Tiazac Adverse Reactions
Adverse Reactions
Headache, pain, dizziness, edema, asthenia, bradycardia, dyspepsia, dyspnea, bronchitis, AV block; CHF, liver abnormalities (rare).
Tiazac Clinical Trials
See Literature
Tiazac Note
Not Applicable
Tiazac Patient Counseling
See Literature
Tiazac Generic Name & Formulations
Legal Class
Rx
General Description
Diltiazem HCl 120mg, 180mg, 240mg, 300mg, 360mg, 420mg; ext-rel beads in caps.
Pharmacological Class
Calcium channel blocker (CCB) (benzothiazepine).
How Supplied
Caps—30, 90, 1000
Manufacturer
Generic Availability
YES
Mechanism of Action
The therapeutic effects of diltiazem HCl are believed to be related to its ability to
inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. Diltiazem HCl produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance.
Tiazac Indications
Indications
Hypertension.
Tiazac Dosage and Administration
Adult
May sprinkle contents on applesauce; do not crush or chew contents. Initially 120–240mg once daily; adjust at 2-week intervals; usual max 540mg/day.
Children
Not established.
Tiazac Contraindications
Contraindications
Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Severe hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.
Tiazac Boxed Warnings
Not Applicable
Tiazac Warnings/Precautions
Warnings/Precautions
Heart failure. Impaired renal or hepatic function. Monitor liver function. Discontinue if persistent rash occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Tiazac Pharmacokinetics
Elimination
Renal. Half-life: ~3–4.5hrs.
Tiazac Interactions
Interactions
Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, ivabradine (avoid), simvastatin (limit simvastatin dose to 10mg/day), quinidine; consider dose adjustments; monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.
Tiazac Adverse Reactions
Adverse Reactions
Edema, headache, dizziness, asthenia, 1st-degree AV block, bradycardia, flushing, nausea, rash; CHF, liver abnormalities (rare).
Tiazac Clinical Trials
See Literature
Tiazac Note
Not Applicable
Tiazac Patient Counseling
See Literature
