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Tenormin Generic Name & Formulations
Legal Class
Rx
General Description
Atenolol 25mg, 50mg, 100mg; tabs.
Pharmacological Class
Cardioselective beta-blocker.
How Supplied
Tabs—90
Manufacturer
Mechanism of Action
The beta-adrenoreceptor blocking activity of Tenormin has been demonstrated by: reduction in resting and exercise heart rate and cardiac output, reduction of systolic and diastolic blood pressure at rest and on exercise, inhibition of isoproterenol induced tachycardia, and reduction in reflex orthostatic tachycardia.
Tenormin Indications
Indications
Long-term management of angina.
Tenormin Dosage and Administration
Adult
Initially 50mg once daily. May increase after 1 week to 100mg daily; max 200mg/day. Elderly or renal impairment: may need lower dose; monitor trough BP. Coincide a dose for the end of hemodialysis.
Children
Not established.
Tenormin Contraindications
Contraindications
Sinus bradycardia. 2nd- or 3rd-degree heart block. Overt heart failure. Cardiogenic shock.
Tenormin Boxed Warnings
Boxed Warning
Cessation of therapy.
Tenormin Warnings/Precautions
Warnings/Precautions
Bronchospastic disease. Renal dysfunction. Diabetes. May mask signs and increase risk for hypoglycemia. Hyperthyroidism. Pheochromocytoma. Surgery. Avoid abrupt cessation. Peripheral circulatory disorders. Ischemic heart disease or failure. Pregnancy: not recommended. Nursing mothers.
Tenormin Pharmacokinetics
Distribution
Plasma protein bound: 6–16%.
Elimination
Renal. Half-life: ~6–7hrs.
Tenormin Interactions
Interactions
Additive effect with catecholamine-depleting drugs, prazosin, digoxin. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Increased rebound hypertension with clonidine withdrawal. May block epinephrine.
Tenormin Adverse Reactions
Adverse Reactions
Heart failure, bronchospasm, bradycardia, angina, MI, heart block, dizziness, fatigue, GI upset, depression, orthostatic hypotension, cold extremities.
Tenormin Clinical Trials
See Literature
Tenormin Note
Not Applicable
Tenormin Patient Counseling
See Literature
Tenormin Generic Name & Formulations
Legal Class
Rx
General Description
Atenolol 25mg, 50mg, 100mg; tabs.
Pharmacological Class
Cardioselective beta-blocker.
How Supplied
Tabs—90
Manufacturer
Mechanism of Action
The beta-adrenoreceptor blocking activity of Tenormin has been demonstrated by: reduction in resting and exercise heart rate and cardiac output, reduction of systolic and diastolic blood pressure at rest and on exercise, inhibition of isoproterenol induced tachycardia, and reduction in reflex orthostatic tachycardia.
Tenormin Indications
Indications
Hypertension.
Tenormin Dosage and Administration
Adult
Initially 50mg daily. May increase after 1–2 weeks to 100mg once daily; max 100mg/day. Elderly: Initially 25–50mg daily; monitor trough BP. CrCl 15–35mL/minute: max 50mg/day; CrCl <15mL/minute: max 25mg/day; monitor trough BP. Coincide a dose for the end of hemodialysis.
Children
Not established.
Tenormin Contraindications
Contraindications
Sinus bradycardia. 2nd- or 3rd-degree heart block. Overt heart failure. Cardiogenic shock.
Tenormin Boxed Warnings
Boxed Warning
Cessation of therapy.
Tenormin Warnings/Precautions
Warnings/Precautions
Bronchospastic disease. Renal dysfunction. Diabetes. May mask signs and increase risk for hypoglycemia. Hyperthyroidism. Pheochromocytoma. Surgery. Avoid abrupt cessation. Peripheral circulatory disorders. Ischemic heart disease or failure. Pregnancy: not recommended. Nursing mothers.
Tenormin Pharmacokinetics
Distribution
Plasma protein bound: 6–16%.
Elimination
Renal. Half-life: ~6–7hrs.
Tenormin Interactions
Interactions
Additive effect with catecholamine-depleting drugs, prazosin, digoxin. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Increased rebound hypertension with clonidine withdrawal. May block epinephrine.
Tenormin Adverse Reactions
Adverse Reactions
Heart failure, bronchospasm, bradycardia, angina, MI, heart block, dizziness, fatigue, GI upset, depression, orthostatic hypotension, cold extremities.
Tenormin Clinical Trials
See Literature
Tenormin Note
Not Applicable
Tenormin Patient Counseling
See Literature
