Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Tenoretic Generic Name & Formulations
Legal Class
Rx
General Description
Atenolol, chlorthalidone; 50mg/25mg+, 100mg/25mg; tabs; (+) scored.
Pharmacological Class
Cardioselective beta-blocker + diuretic.
How Supplied
Tabs—90
Manufacturer
Mechanism of Action
Atenolol is a beta1-selective (cardioselective) beta-adrenergic receptor blocking agent without membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities. This preferential effect is not absolute, however, and at higher doses, atenolol inhibits beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature.
Chlorthalidone is a monosulfonamyl diuretic which differs chemically from thiazide diuretics in that a double ring system is incorporated in its structure. The site of action appears to be the cortical diluting segment of the ascending limb of Henle's loop of the nephron.
Tenoretic Indications
Indications
Hypertension.
Tenoretic Dosage and Administration
Adult
Switching from monotherapy: initially one 50mg/25mg tab daily; may increase to one 100mg/25mg tab daily. CrCl 15–35mL/minute: max 50mg atenolol/day. CrCl <15mL/minute: max 50mg atenolol every other day.
Children
Not recommended.
Tenoretic Contraindications
Contraindications
Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. Anuria. Sulfonamide allergy.
Tenoretic Boxed Warnings
Not Applicable
Tenoretic Warnings/Precautions
Warnings/Precautions
Heart failure. Bronchospastic disease. Renal or hepatic dysfunction. SLE. Gout. Diabetes. May mask signs and increase risk for hypoglycemia. Asthma. Hyperthyroidism. Hypokalemia. Surgery. Postsympathectomy. Peripheral circulatory disorders. Avoid abrupt cessation. Monitor electrolytes. Excessive diuresis. Potassium supplementation may be needed. Pregnancy. Nursing mothers.
Tenoretic Pharmacokinetics
Distribution
Plasma protein bound: 6–16% (atenolol).
Elimination
Renal. Half-life: 6–7 hours (atenolol); 40–50 hours (chlorthalidone).
Tenoretic Interactions
Interactions
May potentiate hypotension with prazosin, alcohol, catecholamine-depleting drugs, CNS depressants. May increase toxicity of diazoxide, digitalis, lithium. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Adjust antidiabetic medications. Increased rebound hypertension with clonidine withdrawal. May block epinephrine. May increase responsiveness to tubocurarine. ACTH, steroids, amphotericin B increase risk of hypokalemia.
Tenoretic Adverse Reactions
Adverse Reactions
Heart failure, bronchospasm, bradycardia, heart block, dizziness, fatigue, fluid or electrolyte imbalance, hyperuricemia, orthostatic hypotension, GI upset, cold extremities.
Tenoretic Clinical Trials
See Literature
Tenoretic Note
Not Applicable
Tenoretic Patient Counseling
See Literature
