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Tekturna Generic Name & Formulations
Legal Class
Rx
General Description
Aliskiren 150mg, 300mg; tabs.
Pharmacological Class
Direct renin inhibitor.
How Supplied
Tabs—30, 90
Manufacturer
Generic Availability
YES
Tekturna Indications
Indications
Hypertension.
Tekturna Dosage and Administration
Adults and Children
<6yrs (<20kg): not established. ≥6yrs (≥50kg): initially 150mg once daily, may increase to 300mg once daily if BP not adequately controlled. May be given with other antihypertensives (see full labeling).
Tekturna Contraindications
Contraindications
Concomitant ARBs or ACEIs in diabetes. Children <2yrs of age.
Tekturna Boxed Warnings
Boxed Warning
Fetal toxicity.
Tekturna Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before starting therapy or start under close supervision. Discontinue if angioedema or laryngeal edema occurs (have SC epinephrine available). Moderate renal impairment (CrCl <60mL/min): avoid concomitant ARBs or ACEIs. Monitor BP, electrolytes, and renal function periodically. Consider withholding or discontinuing if significant renal dysfunction develops. Renal artery stenosis. Severe HF. Post-MI. Diabetes. Children 2–<6yrs (<20kg): avoid. Neonates. Pregnancy: avoid. Nursing mothers: not recommended.
Tekturna Pharmacokinetics
See Literature
Tekturna Interactions
Interactions
Avoid concomitant cyclosporine, itraconazole. Caution with NSAIDs, K+ supplements, K+ sparing diuretics, K+ containing salt substitutes; may cause hyperkalemia. May be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. Dual inhibition of the renin-angiotensin system with ARBs or ACEIs may increase risk of hypotension, hyperkalemia, renal function changes. Concomitant furosemide; monitor. Decreased absorption with high fat meals.
Tekturna Adverse Reactions
Adverse Reactions
Diarrhea, hypotension, cough, rash, edema, elevated uric acid, gout, renal stones; rare: angioedema.
Tekturna Clinical Trials
See Literature
Tekturna Note
Not Applicable
Tekturna Patient Counseling
See Literature
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