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Tadliq Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Susp—150mL
Manufacturer
Generic Availability
NO
Tadliq Indications
Indications
Pulmonary arterial hypertension (WHO Group I) to improve exercise ability.
Tadliq Dosage and Administration
Adult
40mg (10mL) once daily. Mild (CrCl 51–80mL/min) or moderate (CrCl 31–50mL/min) renal impairment: initially 20mg (5mL) once daily; increase to 40mg (10mL) once daily if tolerated. Severe renal impairment (CrCl <30mL/min, on hemodialysis): avoid. Mild or moderate hepatic cirrhosis (Child Pugh Class A or B): consider starting at 20mg (5mL) once daily. Severe hepatic cirrhosis (Child Pugh Class C): avoid. Use with ritonavir: patients receiving ritonavir (for at least 1 week): initiate tadalafil at 20mg (5mL) once daily, may increase to 40mg (10mL) once daily if tolerated; patients already on tadalafil: stop tadalafil at least 24hrs prior to initiating ritonavir; resume tadalafil at 20mg (5mL) once daily after at least 1 week; may increase to 40mg (10mL) once daily if tolerated.
Children
Not established.
Tadliq Contraindications
Contraindications
Concomitant organic nitrates, guanylate cyclase stimulators (eg, riociguat).
Tadliq Boxed Warnings
Not Applicable
Tadliq Warnings/Precautions
Warnings/Precautions
Underlying cardiovascular disease. Preexisting hypotension, autonomic dysfunction, left ventricular outflow obstruction. Pulmonary veno-occlusive disease, severe renal and hepatic impairment, hereditary degenerative retinal disorders including retinitis pigmentosa: not recommended. Monitor for pulmonary edema. Anatomical penile deformation. Predisposition to priapism. History of non-arteritic anterior ischemic optic neuropathy (NAION). "Crowded" optic disc. Pregnancy. Nursing mothers.
Tadliq Pharmacokinetics
See Literature
Tadliq Interactions
Interactions
See Contraindications. Hypotension with nitrates; do not use nitrates within 48hrs of the last tadalafil dose. Avoid concomitant potent CYP3A inhibitors (eg, ketoconazole, itraconazole) and potent CYP3A inducers (eg, rifampin). Concomitant α-blockers (eg, doxazosin, alfuzosin, tamsulosin), alcohol may cause symptomatic hypotension. Concomitant other tadalafil products (eg, Cialis) or PDE5 inhibitors: not recommended. Caution with ritonavir (see Adult dose).
Tadliq Adverse Reactions
Adverse Reactions
Headache, myalgia, nasopharyngitis, flushing, respiratory tract infection, pain, nausea, dyspepsia, sinus congestion; hypotension, sudden vision or hearing loss, priapism, prolonged erection, NAION.
Tadliq Clinical Trials
See Literature
Tadliq Note
Not Applicable
Tadliq Patient Counseling
See Literature
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