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Sular Generic Name & Formulations
Legal Class
Rx
General Description
Nisoldipine 8.5mg, 17mg*, 34mg; ext-rel tabs; *contains tartrazine.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
How Supplied
Tabs—100
Manufacturer
Sular Indications
Indications
Hypertension.
Sular Dosage and Administration
Adult
Swallow whole. Take on an empty stomach (1hr before or 2hrs after a meal). Initially 17mg once daily; may increase by 8.5mg per week or longer intervals. Usual maintenance: 17–34mg once daily; max 34mg/day. Hepatic impairment or elderly (>65yrs): Initially 8.5mg once daily.
Children
Not established.
Sular Contraindications
Not Applicable
Sular Boxed Warnings
Not Applicable
Sular Warnings/Precautions
Warnings/Precautions
Coronary artery disease. Heart failure or compromised ventricular function (esp. with a beta-blocker). Monitor BP closely during initiation and titration. Severe hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Sular Pharmacokinetics
See Literature
Sular Interactions
Interactions
Avoid concomitant CYP3A4 inhibitors or inducers, grapefruit juice. High-fat meals increase peak drug concentrations. Antagonized by phenytoin (avoid; consider alternatives). May be potentiated by cimetidine.
Sular Adverse Reactions
Adverse Reactions
Peripheral edema, headache, dizziness, pharyngitis, vasodilation, sinusitis, palpitations, chest pain, nausea, rash; increased angina, MI (rare), hypotension.
Sular Clinical Trials
See Literature
Sular Note
Not Applicable
Sular Patient Counseling
See Literature
