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Soaanz Generic Name & Formulations
Legal Class
Rx
General Description
Torsemide 20mg, 40mg, 60mg; tabs.
Pharmacological Class
Diuretic (loop).
How Supplied
Tabs—30, 90
Manufacturer
Generic Availability
NO
Soaanz Indications
Indications
Edema associated with heart failure or renal disease.
Soaanz Dosage and Administration
Adult
Initially 20mg orally once daily. If inadequate, titrate upwards by doubling dose until desired response; max: 200mg/day.
Children
Not established.
Soaanz Contraindications
Contraindications
Anuria. Hepatic coma.
Soaanz Boxed Warnings
Not Applicable
Soaanz Warnings/Precautions
Warnings/Precautions
Hypotension. Renal impairment. Monitor volume status, renal function, BP, electrolytes, blood glucose. High doses, severe renal impairment, or hypoproteinemia may increase the risk of ototoxicity. Pregnancy. Nursing mothers.
Soaanz Pharmacokinetics
See Literature
Soaanz Interactions
Interactions
Concomitant NSAIDs may decrease diuretic, natriuretic (eg, indomethacin), and antihypertensive effects; risk of renal impairment. Lithium or salicylate toxicity. Potentiated by concomitant CYP2C9 inhibitors (eg, amiodarone, fluconazole, miconazole, oxandrolone); monitor and adjust dose if needed. Antagonized by concomitant CYP2C9 inducers (eg, rifampin); monitor and adjust dose if needed. May affect sensitive CYP2C9 substrates or substrates with narrow therapeutic range (eg, celecoxib, warfarin, phenytoin); monitor and adjust dose if needed. Give oral dose 1hr before or 4–6hrs after cholestyramine. Antagonized by organic anion drugs (eg, probenecid). Ototoxicity with aminoglycosides (avoid) or ethacrynic acid. Risk of hypotension and/or renal impairment with concomitant ACE inhibitors, ARBs, or nephrotoxic drugs. Increased nephrotoxicity with concomitant radiocontrast agents. Increased risk of hypokalemia with concomitant corticosteroids or ACTH.
Soaanz Adverse Reactions
Adverse Reactions
Excessive urination; dehydration, volume depletion, hypotension, worsening renal function, electrolyte and metabolic abnormalities, hyperglycemia, hyperuricemia, tinnitus, hearing loss; rare: gout.
Soaanz Clinical Trials
See Literature
Soaanz Note
Not Applicable
Soaanz Patient Counseling
See Literature
