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Reserpine Generic Name & Formulations
Legal Class
Rx
General Description
Reserpine 0.1mg, 0.25mg; tabs.
Pharmacological Class
Rauwolfia compound.
How Supplied
Tabs—100, 1000, 5000
Manufacturer
Reserpine Indications
Indications
Mild essential hypertension. Adjunctive therapy with other antihypertensive agents in more severe forms of hypertenstion.
Reserpine Dosage and Administration
Adult
Usual initial dose: 0.5mg daily for 1 or 2 weeks. Maintenance: reduce to 0.1–0.25mg daily.
Children
Usually not recommended; if used, starting dose: 20mcg/kg daily; max 0.25mg daily.
Reserpine Contraindications
Contraindications
Depression or history of (esp. with suicidal tendencies). Active peptic ulcer. Ulcerative colitis. Electroconvulsive therapy.
Reserpine Boxed Warnings
Not Applicable
Reserpine Warnings/Precautions
Warnings/Precautions
Discontinue at first signs of depression. History of peptic ulcer, ulcerative colitis, gallstones (biliary colic may be precipitated). Renal impairment. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Reserpine Pharmacokinetics
See Literature
Reserpine Interactions
Interactions
MAOIs: avoid or use with extreme caution. Concomitant tricyclics may decrease antihypertensive effects. May potentiate direct-acting amines (eg, epinephrine, isoproterenol, phenylephrine, metaraminol). May antagonize indirect-acting amines (eg, ephedrine, tyramine, amphetamines). Caution with digoxin, quinidine, other antihypertensive agents.
Reserpine Adverse Reactions
Adverse Reactions
GI upset, dry mouth, hypersecretion, arrhythmias, syncope, angina-like symptoms, bradycardia, edema, dyspnea, epistaxis, nasal congestion, dizziness, headache, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium, drowsiness, muscle aches, pseudolactation, impotence, dysuria, gynecomastia, decreased libido, weight gain, deafness, optic atrophy, glaucoma, uveitis, conjunctival injection, purpura, rash, pruritus; rare: parkinsonian syndrome and other extrapyramidal symptoms.
Reserpine Clinical Trials
See Literature
Reserpine Note
Not Applicable
Reserpine Patient Counseling
See Literature
Reserpine Generic Name & Formulations
Legal Class
Rx
General Description
Reserpine 0.1mg, 0.25mg; tabs.
Pharmacological Class
Rauwolfia compound.
How Supplied
Tabs—100, 1000, 5000
Manufacturer
Reserpine Indications
Indications
Relief of symptoms in agitated psychotic states (eg, schizophrenia), primarily in those unable to tolerate phenothiazine derivatives or in those who require antihypertensive medication.
Reserpine Dosage and Administration
Adult
Individualize. Usual initial dose: 0.5mg daily, may range from 0.1–1mg.
Children
Not recommended.
Reserpine Contraindications
Contraindications
Depression or history of (esp. with suicidal tendencies). Active peptic ulcer. Ulcerative colitis. Electroconvulsive therapy.
Reserpine Boxed Warnings
Not Applicable
Reserpine Warnings/Precautions
Warnings/Precautions
Discontinue at first signs of depression. History of peptic ulcer, ulcerative colitis, gallstones (biliary colic may be precipitated). Renal impairment. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Reserpine Pharmacokinetics
See Literature
Reserpine Interactions
Interactions
MAOIs: avoid or use with extreme caution. Concomitant tricyclics may decrease antihypertensive effects. May potentiate direct-acting amines (eg, epinephrine, isoproterenol, phenylephrine, metaraminol). May antagonize indirect-acting amines (eg, ephedrine, tyramine, amphetamines). Caution with digoxin, quinidine, other antihypertensive agents.
Reserpine Adverse Reactions
Adverse Reactions
GI upset, dry mouth, hypersecretion, arrhythmias, syncope, angina-like symptoms, bradycardia, edema, dyspnea, epistaxis, nasal congestion, dizziness, headache, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium, drowsiness, muscle aches, pseudolactation, impotence, dysuria, gynecomastia, decreased libido, weight gain, deafness, optic atrophy, glaucoma, uveitis, conjunctival injection, purpura, rash, pruritus; rare: parkinsonian syndrome and other extrapyramidal symptoms.
Reserpine Clinical Trials
See Literature
Reserpine Note
Not Applicable
Reserpine Patient Counseling
See Literature
