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Quinidine Gluconate Generic Name & Formulations
Legal Class
Rx
General Description
Quinidine gluconate 324mg; ext-rel tabs.
Pharmacological Class
Class I antiarrhythmic.
How Supplied
Contact supplier.
Manufacturer
Quinidine Gluconate Indications
Indications
Atrial and ventricular arrhythmias (see full labeling).
Quinidine Gluconate Dosage and Administration
Adult
Take with fluid and in an upright position. Individualize. Prevention of premature atrial, nodal and ventricular contractions: 324–648mg every 8–12 hrs. Maintenance of sinus rhythm following cardioversion: 648mg every 12 hrs or 486–648mg every 8 hrs.
Children
Not recommended.
Quinidine Gluconate Contraindications
Contraindications
Complete AV or bundle branch block or other severe intraventricular conduction defects. Myasthenia gravis. Digitalis intoxication. Aberrant impulses, abnormal rhythms due to escape mechanisms.
Quinidine Gluconate Boxed Warnings
Not Applicable
Quinidine Gluconate Warnings/Precautions
Warnings/Precautions
Atrial flutter; digitalize first. Incomplete AV block. Heart failure. Marginally compensated cardiovascular disease. Hypotension. Renal and hepatic dysfunction. Monitor blood, liver and kidney function in long-term use. Monitor ECG and serum levels if dose is over 2.5g/day. Pregnancy (Cat.C). Nursing mothers.
Quinidine Gluconate Pharmacokinetics
See Literature
Quinidine Gluconate Interactions
Interactions
Quinidine toxicity increased by amiodarone, cimetidine, ranitidine, diuretics, carbonic anhydrase inhibitors, sodium bicarbonate, verapamil, diltiazem. Potentiates anticoagulants, anticholinergics, neuromuscular blocking agents, phenothiazines, reserpine, timolol. Increases digitalis serum levels. Quinidine levels decreased by barbiturates, hydantoins, rifampin, nifedipine.
Quinidine Gluconate Adverse Reactions
Adverse Reactions
Nausea, vomiting, abdominal pain, diarrhea, new or exacerbated arrhythmias, heart block, syncope, cinchonism, headache, blood dyscrasias, hypotension, flushing, allergic reactions, impaired hearing and vision, hepatic dysfunction.
Quinidine Gluconate Clinical Trials
See Literature
Quinidine Gluconate Note
Notes
Formerly known under the brand names Duraquin, Quinact, Quinaglute.
Quinidine Gluconate Patient Counseling
See Literature
