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Prostin Vr Pediatric Generic Name & Formulations
Legal Class
Rx
General Description
Alprostadil 500mcg/mL; soln for IV infusion after dilution; contains dehydrated alcohol.
Pharmacological Class
Prostaglandin E1.
How Supplied
Ampules (1mL)—5
Manufacturer
Prostin Vr Pediatric Indications
Indications
Palliative therapy to maintain ductus arteriosus patency until corrective or palliative surgery can be performed in neonates with congenital heart defects and who depend on patent ductus for survival.
Prostin Vr Pediatric Dosage and Administration
Adult
Not applicable.
Children
Use lowest effective dose for shortest duration. Give by continuous IV infusion into large vein (preferred) or through an umbilical artery catheter placed at the ductal opening. Initially 0.05–0.1mcg/kg/min. Reduce dose from 0.1 to 0.05 to 0.025 to 0.01mcg/kg/min after therapeutic response is achieved to provide lowest dose that maintains response. If inadequate response to 0.05mcg/kg/min; may increase up to 0.4mcg/kg/min.
Prostin Vr Pediatric Contraindications
Not Applicable
Prostin Vr Pediatric Boxed Warnings
Boxed Warning
Apnea in neonates with congenital heart defects; use where ventilatory assistance is immediately available.
Prostin Vr Pediatric Warnings/Precautions
Warnings/Precautions
Respiratory distress syndrome: not recommended. Bleeding disorders. Prolonged therapy (>120hrs): monitor for antral hyperplasia and gastric outlet obstruction. Monitor respiratory status, arterial pressure, blood oxygenation, BP, blood pH; decrease infusion rate if arterial pressure falls significantly. Neonates <2kg at birth.
Prostin Vr Pediatric Pharmacokinetics
See Literature
Prostin Vr Pediatric Interactions
Interactions
Caution with anticoagulants.
Prostin Vr Pediatric Adverse Reactions
Adverse Reactions
Apnea, fever, flushing, bradycardia, hypotension, tachycardia, seizures, diarrhea, sepsis, cortical proliferation of the long bones (long-term infusion).
Prostin Vr Pediatric Clinical Trials
See Literature
Prostin Vr Pediatric Note
Not Applicable
Prostin Vr Pediatric Patient Counseling
See Literature
