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Propranolol Hcl Injection Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 1mg/mL; soln for IV inj.
Pharmacological Class
Beta-blocker.
How Supplied
Contact supplier.
Manufacturer
Propranolol Hcl Injection Indications
Indications
Supraventricular arrhythmias (see literature). Ventricular tachycardias (not first-line). Tachyarrhythmias of digitalis intoxication. Resistant tachyarrythmias due to excessive catecholamine action during anesthesia.
Propranolol Hcl Injection Dosage and Administration
Adult
Usual dose: 1–3mg IV at a rate of 1mg/min. If necessary, a second dose may be given after 2 minutes. Thereafter, additional drug should not be given in less than 4 hours. Transfer to oral therapy as soon as possible.
Children
Not recommended.
Propranolol Hcl Injection Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Cardiogenic shock.
Propranolol Hcl Injection Boxed Warnings
Not Applicable
Propranolol Hcl Injection Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Propranolol Hcl Injection Pharmacokinetics
See Literature
Propranolol Hcl Injection Interactions
Interactions
Potentiated by CNS depressants, other antihypertensives, haloperidol, propafenone, quinidine, disopyramide, amiodarone. Bradycardia with catecholamine-depleting drugs (eg, reserpine). Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. Caution with drugs that slow A-V nodal conduction (eg, calcium channel blockers, digitalis, lidocaine). Potentiates theophylline, antipyrine, lidocaine. Antihypertensive effects of clonidine may be antagonized. Concomitant methoxyflurane, trichloroethylene may depress myocardial contractility. Concomitant thyroxine may result in lower T3 concentration. May block epinephrine. May interfere with glaucoma screening tests. Monitor prothrombin time with warfarin.
Propranolol Hcl Injection Adverse Reactions
Adverse Reactions
Bradycardia, CHF, intensification of AV block, hypotension, CNS effects, GI upset, pharyngitis, rash, bronchospasm, blood dyscrasias; rare: SLE.
Propranolol Hcl Injection Clinical Trials
See Literature
Propranolol Hcl Injection Note
Not Applicable
Propranolol Hcl Injection Patient Counseling
See Literature
