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Procardia Xl Generic Name & Formulations
Legal Class
Rx
General Description
Nifedipine 30mg, 60mg, 90mg; ext-rel tabs.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
See Also
How Supplied
Tabs 30mg, 60mg—100, 300; 90mg—100; Caps—100
Manufacturer
Procardia Xl Indications
Indications
Vasospastic and chronic stable angina.
Procardia Xl Dosage and Administration
Adult
Swallow whole. Initially 30 or 60mg once daily, titrate over 7–14 days; usual max 90mg/day.
Children
Not established.
Procardia Xl Contraindications
Not Applicable
Procardia Xl Boxed Warnings
Not Applicable
Procardia Xl Warnings/Precautions
Warnings/Precautions
Aortic stenosis. Severe obstructive coronary artery disease. Avoid administration within 1–2 weeks post MI or in acute coronary syndrome. Heart failure. GI narrowing/ulcers (tabs). Monitor blood pressure initially and during titration. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.
Procardia Xl Pharmacokinetics
See Literature
Procardia Xl Interactions
Interactions
Severe hypotension, angina, and CHF possible with beta-blockers. Avoid concomitant phenytoin or CYP3A4 inducers; consider alternative antihypertensive therapy. Avoid concomitant grapefruit or grapefruit juice. Potentiated by CYP3A inhibitors (eg, fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir), or cimetidine; consider initiating nifedipine at lowest dose. Potentiates digoxin (monitor). Hypotension possible with fentanyl. GI obstruction possible with H2-blockers, opiates, NSAIDs, laxatives, anticholinergics, levothyroxine, neuromuscular blockers. Monitor oral anticoagulants, quinidine. Taper beta-blockers before initiating nifedipine.
Procardia Xl Adverse Reactions
Adverse Reactions
Edema, dizziness, nausea, headache, flushing, weakness, hypotension, fatigue, constipation, palpitations, muscle cramps; rare: increased angina, acute MI, elevated enzymes.
Procardia Xl Clinical Trials
See Literature
Procardia Xl Note
Not Applicable
Procardia Xl Patient Counseling
See Literature
Procardia Xl Generic Name & Formulations
Legal Class
Rx
General Description
Nifedipine 30mg, 60mg, 90mg; ext-rel tabs.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
See Also
How Supplied
Tabs 30mg, 60mg—100, 300; 90mg—100
Manufacturer
Procardia Xl Indications
Indications
Hypertension.
Procardia Xl Dosage and Administration
Adult
Swallow whole. Initially 30 or 60mg once daily, titrate over 7–14 days; max 120mg/day.
Children
Not established.
Procardia Xl Contraindications
Not Applicable
Procardia Xl Boxed Warnings
Not Applicable
Procardia Xl Warnings/Precautions
Warnings/Precautions
Aortic stenosis. Severe obstructive coronary artery disease. Heart failure. GI narrowing/ulcers (tabs). Monitor blood pressure initially and during titration. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.
Procardia Xl Pharmacokinetics
See Literature
Procardia Xl Interactions
Interactions
Severe hypotension, angina, and CHF possible with beta-blockers. Avoid concomitant phenytoin or CYP3A4 inducers; consider alternative antihypertensive therapy. Avoid concomitant grapefruit or grapefruit juice. Potentiated by CYP3A inhibitors (eg, fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir), or cimetidine; consider initiating nifedipine at lowest dose. Potentiates digoxin (monitor). Hypotension possible with fentanyl. GI obstruction possible with H2-blockers, opiates, NSAIDs, laxatives, anticholinergics, levothyroxine, neuromuscular blockers. Monitor oral anticoagulants, quinidine. Taper beta-blockers before initiating nifedipine.
Procardia Xl Adverse Reactions
Adverse Reactions
Edema, dizziness, nausea, headache, flushing, weakness, hypotension, fatigue, constipation, palpitations, muscle cramps; rare: increased angina, acute MI, elevated enzymes.
Procardia Xl Clinical Trials
See Literature
Procardia Xl Note
Not Applicable
Procardia Xl Patient Counseling
See Literature
