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Procardia Generic Name & Formulations
Legal Class
Rx
General Description
Nifedipine 10mg; caps.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
See Also
How Supplied
Tabs 30mg, 60mg—100, 300; 90mg—100; Caps—100
Manufacturer
Procardia Indications
Indications
Vasospastic and chronic stable angina.
Procardia Dosage and Administration
Adult
Initially 10mg three times daily, titrate over 7–14 days (for faster titration: see full labeling). Usual range 10–20mg three times daily; max 30mg/dose and 180mg/day.
Children
Not established.
Procardia Contraindications
Not Applicable
Procardia Boxed Warnings
Not Applicable
Procardia Warnings/Precautions
Warnings/Precautions
Aortic stenosis. Severe obstructive coronary artery disease. Avoid administration within 1–2 weeks post MI or in acute coronary syndrome. Heart failure. GI narrowing/ulcers (tabs). Monitor blood pressure initially and during titration. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.
Procardia Pharmacokinetics
See Literature
Procardia Interactions
Interactions
Severe hypotension, angina, and CHF possible with beta-blockers. Avoid concomitant phenytoin or CYP3A4 inducers; consider alternative antihypertensive therapy. Avoid concomitant grapefruit or grapefruit juice. Potentiated by CYP3A inhibitors (eg, fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir), or cimetidine; consider initiating nifedipine at lowest dose. Potentiates digoxin (monitor). Hypotension possible with fentanyl. GI obstruction possible with H2-blockers, opiates, NSAIDs, laxatives, anticholinergics, levothyroxine, neuromuscular blockers. Monitor oral anticoagulants, quinidine. Taper beta-blockers before initiating nifedipine.
Procardia Adverse Reactions
Adverse Reactions
Edema, dizziness, nausea, headache, flushing, weakness, hypotension, fatigue, constipation, palpitations, muscle cramps; rare: increased angina, acute MI, elevated enzymes.
Procardia Clinical Trials
See Literature
Procardia Note
Not Applicable
Procardia Patient Counseling
See Literature
