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Phoxillum Generic Name & Formulations
Legal Class
Rx
General Description
BK4/2.5 (Ca2+ 2.5mEq/L, HCO3- 32mEq/L, K+ 4mEq/L, Mg2+ 1.5mEq/L, Na+ 140mEq/L, HPO42- 1mmol/L, Cl- 114.5mEq/L); B22K4/0 (HCO3- 22mEq/L, K+ 4mEq/L, Mg2+ 1.5mEq/L, Na+ 140mEq/L, HPO42- 1mmol/L, Cl- 122mEq/L); soln for IV inf after reconstitution.
Pharmacological Class
Fluid & electrolyte replacement.
How Supplied
2-compartment bag (5000mL)—1
Manufacturer
Generic Availability
NO
Phoxillum Indications
Indications
Replacement solution for patients on continuous renal replacement therapy (CRRT), to replace plasma volume removed by ultrafiltration and correct electrolyte and acid-base imbalances. To remove dialyzable toxins associated with drug poisoning treated by CRRT.
Phoxillum Dosage and Administration
Adults and Children
Administer only under the direction of a physician trained in intensive care treatment including CRRT: see full labeling. Individualize; determine mode of therapy, solute formulation, flow rates, and duration based on patient’s clinical condition and electrolyte, acid-base, and glucose balances. Administer into extracorporeal circuit before (pre-dilution) and/or after (post-dilution) the hemofilter or hemodiafilter.
Phoxillum Contraindications
Not Applicable
Phoxillum Boxed Warnings
Not Applicable
Phoxillum Warnings/Precautions
Warnings/Precautions
Use aseptic technique. Monitor fluid, hemodynamic, electrolyte, and acid-base imbalances; correct as needed. Increased risk of metabolic acidosis. Monitor blood glucose levels; initiate or modify antidiabetic therapy as needed. Pregnancy, nursing mothers: monitor.
Phoxillum Pharmacokinetics
See Literature
Phoxillum Interactions
Interactions
May antagonize dialyzable drugs: monitor. Concomitant citrate (as anticoagulant) may reduce plasma calcium; select appropriate Phoxillum formulation. May add drugs to bag via injection connector; administer non-phosphate drugs through different access line.
Phoxillum Adverse Reactions
Adverse Reactions
Metabolic acidosis, hypotension, acid-base disorders, electrolyte and fluid imbalance.
Phoxillum Clinical Trials
See Literature
Phoxillum Note
Not Applicable
Phoxillum Patient Counseling
See Literature
