Phentolamine

— THERAPEUTIC CATEGORIES —
  • Hypertension

Phentolamine Generic Name & Formulations

General Description

Phentolamine mesylate 5mg/vial; for IM or IV inj after reconstitution; contains mannitol.

Pharmacological Class

Alpha adrenergic blocker.

How Supplied

Vial—1

Phentolamine Indications

Indications

Hypertensive episodes in patients with pheochromocytoma.

Phentolamine Dosage and Administration

Adult

Pre-op: 5mg IV or IM 1–2 hrs before surgery; may repeat. During surgery: 5mg IV as needed. See literature.

Children

Pre-op: 1mg IV or IM 1–2 hrs before surgery; may repeat. During surgery: 1mg IV as needed. See literature.

Phentolamine Contraindications

Contraindications

MI or history of MI. Coronary insufficiency. Angina. Coronary artery disease.

Phentolamine Boxed Warnings

Not Applicable

Phentolamine Warnings/Precautions

Warnings/Precautions

Arrhythmias. Pregnancy (Cat.C). Nursing mothers: not recommended.

Phentolamine Pharmacokinetics

See Literature

Phentolamine Interactions

Interactions

Avoid concomitant cardiac glycosides.

Phentolamine Adverse Reactions

Adverse Reactions

Cerebrovascular spasms or occlusion, MI, tachycardia, arrhythmias, hypotension, weakness, dizziness, flushing, nasal congestion, GI disturbances.

Phentolamine Clinical Trials

See Literature

Phentolamine Note

Notes

Formerly known under the brand name Regitine.

Phentolamine Patient Counseling

See Literature