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Northera Generic Name & Formulations
Legal Class
Rx
General Description
Droxidopa 100mg, 200mg, 300mg+; capsules; (+) contains tartrazine.
Pharmacological Class
Norepinephrine prodrug.
How Supplied
Caps—90
Manufacturer
Generic Availability
NO
Northera Indications
Indications
Symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure (Parkinson's disease, multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy.
Northera Dosage and Administration
Adult
Swallow whole. Take with or without food. Initially 100mg three times daily in the morning, midday, and late afternoon (≥3hrs prior to bedtime). Titrate in increments of 100mg three times daily every 24–48hrs; max 600mg three times daily.
Children
Not established.
Northera Contraindications
Not Applicable
Northera Boxed Warnings
Boxed Warning
Supine hypertension.
Northera Warnings/Precautions
Warnings/Precautions
May cause or exacerbate supine hypertension. Monitor BP (supine and head-elevated sleeping positions) prior to initiating and after increasing the dose; reduce dose or discontinue if supine hypertension persists. Monitor for symptoms of neuroleptic malignant syndrome; observe carefully during dose changes or when concomitant levodopa is reduced abruptly or discontinued, especially if receiving neuroleptics. May exacerbate ischemic heart disease, arrhythmias, CHF. Discontinue if hypersensitivity reactions occur. Allergic reactions (tartrazine). Reevaluate periodically. Severe renal impairment (GFR <30mL/min): limited data. Pregnancy. Nursing mothers: not recommended.
Northera Pharmacokinetics
See Literature
Northera Interactions
Interactions
Concomitant drugs that increase BP (eg, norepinephrine, ephedrine, midodrine, and triptans); increased risk of supine hypertension. Concomitant dopa-decarboxylase inhibitors: may need to adjust droxidopa dose. Avoid concomitant non-selective MAOIs or linezolid.
Northera Adverse Reactions
Adverse Reactions
Headache, dizziness, nausea, hypertension, falls, UTI, syncope; hyperpyrexia, confusion.
Northera Clinical Trials
See Literature
Northera Note
Not Applicable
Northera Patient Counseling
See Literature
