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Nitromist Generic Name & Formulations
Legal Class
Rx
General Description
Nitroglycerin 0.4mg/actuation; lingual aerosol spray.
Pharmacological Class
Nitrate.
How Supplied
Bottles—4.1g (90 metered sprays), 8.5g (230 metered sprays)
Manufacturer
Nitromist Indications
Indications
Acute attacks and prophylaxis of angina.
Nitromist Dosage and Administration
Adult
1–2 sprays at onset of attack, on or under tongue while sitting; may repeat every 5 minutes as needed; max 3 sprays/15 minutes. May use prophylactically 5–10 minutes before exertion. Do not inhale spray. Do not rinse mouth for 5–10 minutes after use.
Children
Not established.
Nitromist Contraindications
Contraindications
Concomitant PDE5 inhibitors (eg, sildenafil, vardenafil, tadalafil), riociguat. Severe anemia. Increased intracranial pressure. Acute circulatory failure. Shock.
Nitromist Boxed Warnings
Not Applicable
Nitromist Warnings/Precautions
Warnings/Precautions
Volume depletion. Hypotension. Acute MI. CHF. Hypertrophic cardiomyopathy. Monitor for tolerance. Product is flammable. Elderly. Pregnancy. Nursing mothers.
Nitromist Pharmacokinetics
See Literature
Nitromist Interactions
Interactions
See Contraindications. Hypotension potentiated with PDE5 inhibitors, riociguat, antihypertensives, β-blockers, calcium channel blockers, alcohol. May be potentiated by aspirin. Nitroglycerin (IV) may antagonize t-PA, heparin (monitor APTT). Avoid concomitant ergotamine and related drugs. Do not use epinephrine to treat hypotension from nitrate overdose.
Nitromist Adverse Reactions
Adverse Reactions
Headache (may be severe), flushing, rash, hypotension.
Nitromist Clinical Trials
See Literature
Nitromist Note
Not Applicable
Nitromist Patient Counseling
See Literature
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