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Nitro-dur Generic Name & Formulations
Legal Class
Rx
General Description
Nitroglycerin 0.1mg/hr, 0.2mg/hr, 0.3mg/hr, 0.4mg/hr, 0.6mg/hr, 0.8mg/hr; transdermal patches.
Pharmacological Class
Nitrate.
How Supplied
Patch—30
Manufacturer
Mechanism of Action
The principal pharmacological action is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload).
Nitro-dur Indications
Indications
Prophylaxis of angina. Not for acute attacks.
Nitro-dur Dosage and Administration
Adult
Initially one 0.2–0.4mg/hr patch for 12–14hr/day. Remove patch for 10–12hrs/day.
Children
Not established.
Nitro-dur Contraindications
Contraindications
Concomitant PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil), riociguat.
Nitro-dur Boxed Warnings
Not Applicable
Nitro-dur Warnings/Precautions
Warnings/Precautions
Acute MI. Volume depletion. Hypotension. Heart failure. Hypertrophic cardiomyopathy. Reduce dose if hypotension occurs. Remove before defibrillation or cardioversion. Elderly. Pregnancy (Cat.C). Nursing mothers.
Nitro-dur Pharmacokinetics
Elimination
Half-life: ~3 mins.
Nitro-dur Interactions
Interactions
See Contraindications. Severe hypotension with PDE-5 inhibitors, riociguat. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.
Nitro-dur Adverse Reactions
Adverse Reactions
Headache, increased angina, lightheadedness, syncope, orthostatic hypotension, tachycardia, rash.
Nitro-dur Clinical Trials
See Literature
Nitro-dur Note
Not Applicable
Nitro-dur Patient Counseling
See Literature
