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Nifedipine Ext-rel Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Mechanism of Action
Nifedipine Ext-rel Indications
Indications
Nifedipine Ext-rel Dosage and Administration
Adult
Swallow whole. Initially 30 or 60mg once daily, titrate over 7–14 days; max 120mg/day.
Children
Nifedipine Ext-rel Contraindications
Not Applicable
Nifedipine Ext-rel Boxed Warnings
Not Applicable
Nifedipine Ext-rel Warnings/Precautions
Warnings/Precautions
Aortic stenosis. Severe obstructive coronary artery disease. Heart failure. GI narrowing/ulcers (tabs). Monitor blood pressure initially and during titration. Avoid abrupt cessation. Pregnancy. Nursing mothers.
Nifedipine Ext-rel Pharmacokinetics
See Literature
Nifedipine Ext-rel Interactions
Interactions
Severe hypotension, angina, and CHF possible with beta-blockers. Avoid concomitant phenytoin or CYP3A4 inducers; consider alternative antihypertensive therapy. Avoid concomitant grapefruit or grapefruit juice. Potentiated by CYP3A inhibitors (eg, fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir), or cimetidine; consider initiating nifedipine at lowest dose. Potentiates digoxin (monitor). Hypotension possible with fentanyl. GI obstruction possible with H2-blockers, opiates, NSAIDs, laxatives, anticholinergics, levothyroxine, neuromuscular blockers. Monitor oral anticoagulants, quinidine. Taper beta-blockers before initiating nifedipine.
Nifedipine Ext-rel Adverse Reactions
Adverse Reactions
Edema, headache, flushing, dizziness, fatigue, constipation, muscle cramps; rare: increased angina, acute MI, elevated enzymes.
Nifedipine Ext-rel Clinical Trials
See Literature
Nifedipine Ext-rel Note
Notes
Nifedipine Ext-rel Patient Counseling
See Literature
