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Nicardipine Generic Name & Formulations
Legal Class
Rx
General Description
Nicardipine HCl 20mg, 30mg; caps.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
See Also
How Supplied
Contact supplier.
Manufacturer
Nicardipine Indications
Indications
Chronic stable angina.
Nicardipine Dosage and Administration
Adult
Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg daily. Severe hepatic impairment: initially 20mg twice daily. Renal insufficiency: 20mg 3 times daily and titrate carefully.
Children
<18yrs: not established.
Nicardipine Contraindications
Contraindications
Advanced aortic stenosis.
Nicardipine Boxed Warnings
Not Applicable
Nicardipine Warnings/Precautions
Warnings/Precautions
Exacerbation of angina. Heart failure. Acute cerebral infarction or hemorrhage. Hepatic or renal impairment. Measure blood pressure 1–2hrs and 8hrs after dosing. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nicardipine Pharmacokinetics
See Literature
Nicardipine Interactions
Interactions
Potentiated by cimetidine. Increases serum levels of cyclosporine, tacrolimus; monitor and adjust its dose. Possibly potentiates digoxin; monitor.
Nicardipine Adverse Reactions
Adverse Reactions
Increased angina, hypotension, flushing, headache, pedal edema, asthenia, dizziness, tachycardia, somnolence, GI upset, insomnia.
Nicardipine Clinical Trials
See Literature
Nicardipine Note
Notes
Formerly known under the brand name Cardene.
Nicardipine Patient Counseling
See Literature
Nicardipine Generic Name & Formulations
Legal Class
Rx
General Description
Nicardipine HCl 20mg, 30mg; caps.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
See Also
How Supplied
Caps 20mg, 30mg—contact supplier; IV (10mL amps)—10; Premixed—200mL
Manufacturer
Nicardipine Indications
Indications
Hypertension.
Nicardipine Dosage and Administration
Adult
Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg daily. Severe hepatic impairment: initially 20mg twice daily.
Children
<18yrs: not established.
Nicardipine Contraindications
Contraindications
Advanced aortic stenosis.
Nicardipine Boxed Warnings
Not Applicable
Nicardipine Warnings/Precautions
Warnings/Precautions
Angina. Heart failure. Acute cerebral infarction or hemorrhage. Hepatic or renal impairment. Pheochromocytoma. For caps: measure blood pressure (BP) 1–2 hrs and 8 hrs after dosing. For IV: monitor BP before and during infusion; avoid rapid or excessive reductions, intra-arterial administration or extravasation; switch to oral form when possible. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nicardipine Pharmacokinetics
See Literature
Nicardipine Interactions
Interactions
Potentiated by cimetidine. Increases serum levels of cyclosporine, tacrolimus; monitor and adjust its dose. Possibly potentiates digoxin; monitor.
Nicardipine Adverse Reactions
Adverse Reactions
Increased angina, flushing (caps), headache, pedal edema, asthenia, dizziness, somnolence (caps), tachycardia, GI upset, sweating; ECG abnormalities, orthostatic hypotension, ventricular extrasystoles, local reactions (inj).
Nicardipine Clinical Trials
See Literature
Nicardipine Note
Notes
Formerly known under the brand name Cardene.
Nicardipine Patient Counseling
See Literature
