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Natrecor Generic Name & Formulations
Legal Class
Rx
General Description
Nesiritide 1.5mg/vial; pwd for IV inj after reconstitution and dilution; contains mannitol.
Pharmacological Class
Vasodilator (human B-type natriuretic peptide).
How Supplied
Single-use vials—1
Manufacturer
Generic Availability
NO
Natrecor Indications
Indications
Acutely decompensated CHF with dyspnea at rest or with minimal activity.
Natrecor Dosage and Administration
Adult
2mcg/kg IV bolus once, then 0.01mcg/kg per minute by continuous IV infusion; limited experience with therapy >96 hours. Doses up to 0.03mcg/kg per minute have been used; see full labeling. Reduce dose or discontinue if symptomatic hypotension occurs.
Children
Not established.
Natrecor Contraindications
Contraindications
Persistent systolic BP <100mmHg. Cardiogenic shock.
Natrecor Boxed Warnings
Not Applicable
Natrecor Warnings/Precautions
Warnings/Precautions
Not recommended in significant valvular stenosis, restrictive or obstructive cardiomyopathy, constrictive pericarditis, pericardial tamponade, other conditions where vasodilators are inappropriate, or when cardiac output is dependent on venous return, or in patients with low cardiac filling pressures. Impaired renal function (esp if severe heart failure); monitor serum creatinine during and after therapy until stabilized. Monitor BP closely. Pregnancy. Nursing mothers.
Natrecor Pharmacokinetics
See Literature
Natrecor Interactions
Interactions
Hypotension potentiated by ARBs and/or ACE inhibitors.
Natrecor Adverse Reactions
Adverse Reactions
Hypotension, headache, nausea, back pain, dizziness; hypersensitivity.
Natrecor Clinical Trials
See Literature
Natrecor Note
Not Applicable
Natrecor Patient Counseling
See Literature
