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Monoket Generic Name & Formulations
Legal Class
Rx
General Description
Isosorbide mononitrate 10mg, 20mg; scored tabs.
Pharmacological Class
Nitrate.
How Supplied
Tabs—100
Manufacturer
Monoket Indications
Indications
Prophylaxis and treatment of angina. Not for acute attacks.
Monoket Dosage and Administration
Adult
20mg upon awakening then 20mg 7 hrs later. Small patients: may start with 5mg per dose for 1 day, then increase to 10mg by 2nd or 3rd day (scheduled as above).
Children
Not established.
Monoket Contraindications
Contraindications
Concomitant PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil), riociguat.
Monoket Boxed Warnings
Not Applicable
Monoket Warnings/Precautions
Warnings/Precautions
Acute MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Monitor for tolerance. Pregnancy (Cat.B). Nursing mothers.
Monoket Pharmacokinetics
See Literature
Monoket Interactions
Interactions
See Contraindications. Severe hypotension, syncope, or myocardial ischemia with PDE-5 inhibitors; or hypotension with riociguat. Orthostatic hypotension with alcohol, other vasodilators, calcium channel blockers.
Monoket Adverse Reactions
Adverse Reactions
Headache, dizziness, orthostatic hypotension, GI upset, upper respiratory infection.
Monoket Clinical Trials
See Literature
Monoket Note
Not Applicable
Monoket Patient Counseling
See Literature
