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Moexipril Hcl Generic Name & Formulations
Legal Class
Rx
General Description
Moexipril HCl 7.5mg, 15mg; scored tabs.
Pharmacological Class
ACE inhibitor.
How Supplied
Contact supplier
Manufacturer
Moexipril Hcl Indications
Indications
Hypertension.
Moexipril Hcl Dosage and Administration
Adult
Take 1 hr before meals. Initially and if not on diuretics: 7.5mg once daily; usual range 7.5–30mg/day in 1–2 divided doses. If on diuretic: suspend diuretic for 2–3 days before starting therapy; resume diuretic if BP not controlled by moexipril alone. If diuretic cannot be discontinued: initially 3.75mg once daily. CrCl ≤40mL/min: initially 3.75mg once daily; max 15mg/day.
Children
Not established.
Moexipril Hcl Contraindications
Contraindications
History of ACEI-associated or other angioedema. Concomitant aliskiren in patients with diabetes.
Moexipril Hcl Boxed Warnings
Boxed Warning
Fetal toxicity.
Moexipril Hcl Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Hepatic impairment. Renal impairment: monitor for worsening renal function. Hypovolemia. Correct salt/volume depletion before starting therapy. CHF. Renal artery or aortic stenosis. Cerebrovascular or ischemic heart disease. Diabetes. Dialysis (esp. high-flux membrane). Surgery. Monitor WBCs in collagen vascular disease. Discontinue if angioedema, laryngeal edema, jaundice or markedly elevated liver enzymes occurs. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers: not recommended.
Moexipril Hcl Pharmacokinetics
See Literature
Moexipril Hcl Interactions
Interactions
See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. Excessive hypotension with diuretics. May be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. May increase lithium levels; monitor. Nitritoid reactions with concomitant injectable gold (eg, sodium aurothiomalate); rare.
Moexipril Hcl Adverse Reactions
Adverse Reactions
Cough, dizziness, diarrhea, flu syndrome, fatigue, pharyngitis, flushing, rash, myalgia; angioedema (eg, intestinal), hyperkalemia, hyponatremia; rare: hepatic failure.
Moexipril Hcl Clinical Trials
See Literature
Moexipril Hcl Note
Notes
Formerly known under the brand name Univasc.
Moexipril Hcl Patient Counseling
See Literature
