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Minoxidil Generic Name & Formulations
Legal Class
Rx
General Description
Minoxidil 2.5 mg, 10 mg; scored tabs.
Pharmacological Class
Vasodilator.
How Supplied
Contact supplier.
Manufacturer
Minoxidil Indications
Indications
Refractory hypertension, usually with a diuretic and β-blocker (see literature).
Minoxidil Dosage and Administration
Adult
Initially 5 mg once daily; may increase at 3-day intervals to 10 mg/day, then 20 mg/day, then 40 mg/day (monitor closely if titrated faster). Usual range 10–40 mg/day; max 100 mg/day. If drop in diastolic pressure >30 mmHg, give in 2 divided doses.
Children
Initially 0.2 mg/kg once daily; may increase at 3-day intervals by 50–100%. Usual range 0.25–1 mg/kg per day; max 50 mg/day.
Minoxidil Contraindications
Contraindications
Pheochromocytoma.
Minoxidil Boxed Warnings
Not Applicable
Minoxidil Warnings/Precautions
Warnings/Precautions
Supervise closely. Do not use in patients with history of recurrent pericarditis, or history of recurrent or chronic pericardial effusion. Malignant hypertension. Angina. Post MI. Heart failure. Renal dysfunction. Monitor fluid and electrolyte balance, body weight, and for pericardial effusion. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Minoxidil Pharmacokinetics
See Literature
Minoxidil Interactions
Interactions
Avoid guanethidine (hospitalize until stable if used).
Minoxidil Adverse Reactions
Adverse Reactions
Pericardial effusion or tamponade, pericarditis, salt/fluid retention, cardiac failure, tachycardia, angina, hypertrichosis, rash, GI upset, ECG changes; rare: Stevens-Johnson syndrome, thromobocytopenia, leukopenia.
Minoxidil Clinical Trials
See Literature
Minoxidil Note
Notes
Formerly known under the brand names Loniten, Minodyl.
Minoxidil Patient Counseling
See Literature
