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Microzide Generic Name & Formulations
Legal Class
Rx
General Description
Hydrochlorothiazide 12.5mg; caps.
Pharmacological Class
Diuretic (thiazide).
How Supplied
Caps—100
Manufacturer
Microzide Indications
Indications
Hypertension.
Microzide Dosage and Administration
Adult
12.5mg once daily; usual max 50mg/day.
Children
Not established.
Microzide Contraindications
Contraindications
Anuria. Sulfonamide allergy.
Microzide Boxed Warnings
Not Applicable
Microzide Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Parathyroid disease. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Elderly. Pregnancy. Nursing mothers: not recommended.
Microzide Pharmacokinetics
See Literature
Microzide Interactions
Interactions
May cause digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests. Additive effects with other antihypertensives.
Microzide Adverse Reactions
Adverse Reactions
Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values; acute myopia, angle-closure glaucoma (discontinue if occurs), increased risk for non-melanoma skin cancer.
Microzide Clinical Trials
See Literature
Microzide Note
Not Applicable
Microzide Patient Counseling
See Literature
