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Metolazone Generic Name & Formulations
Legal Class
Rx
General Description
Metolazone 2.5mg, 5mg, 10mg; tabs.
Pharmacological Class
Diuretic (quinazoline).
How Supplied
Contact supplier
Manufacturer
Metolazone Indications
Indications
Edema.
Metolazone Dosage and Administration
Adult
Individualize. 5–20mg once daily.
Children
Not established.
Metolazone Contraindications
Contraindications
Anuria. Hepatic coma or precoma.
Metolazone Boxed Warnings
Not Applicable
Metolazone Warnings/Precautions
Warnings/Precautions
Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.
Metolazone Pharmacokinetics
See Literature
Metolazone Interactions
Interactions
Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.
Metolazone Adverse Reactions
Adverse Reactions
Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).
Metolazone Clinical Trials
See Literature
Metolazone Note
Notes
Formerly known under the brand name Zaroxolyn.
Metolazone Patient Counseling
See Literature
Metolazone Generic Name & Formulations
Legal Class
Rx
General Description
Metolazone 2.5mg, 5mg, 10mg; tabs.
Pharmacological Class
Diuretic (quinazoline).
How Supplied
Contact supplier
Manufacturer
Metolazone Indications
Indications
Hypertension.
Metolazone Dosage and Administration
Adult
Individualize. 2.5–5mg once daily.
Children
Not established.
Metolazone Contraindications
Contraindications
Anuria. Hepatic coma or precoma.
Metolazone Boxed Warnings
Not Applicable
Metolazone Warnings/Precautions
Warnings/Precautions
Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.
Metolazone Pharmacokinetics
See Literature
Metolazone Interactions
Interactions
Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.
Metolazone Adverse Reactions
Adverse Reactions
Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).
Metolazone Clinical Trials
See Literature
Metolazone Note
Notes
Formerly known under the brand name Zaroxolyn.
Metolazone Patient Counseling
See Literature
