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Maxzide Generic Name & Formulations
Legal Class
Rx
General Description
Triamterene 75mg, hydrochlorothiazide 50mg; scored tabs.
Pharmacological Class
Diuretic (K+ sparing) + (thiazide).
See Also
How Supplied
Tabs—100
Manufacturer
Maxzide Indications
Indications
Edema.
Maxzide Dosage and Administration
Adult
Initially one Maxzide-25mg tab/day. Usual dosage: 1–2 Maxzide-25mg tabs or one Maxzide tab once daily. As a substitute for triamterene 50–100mg/day and hydrochlorothiazide 25–50mg/day in less bioavailable form, give one Maxzide-25mg tab/day.
Children
Not established.
Maxzide Contraindications
Contraindications
Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.
Maxzide Boxed Warnings
Boxed Warning
Risk of hyperkalemia.
Maxzide Warnings/Precautions
Warnings/Precautions
Diabetes. Acidosis predisposition. Electrolyte imbalance. Excessive diuresis. History of renal stones. Gout. Asthma. SLE. Surgery. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Elderly. Severely ill. Pregnancy. Nursing mothers: not recommended.
Maxzide Pharmacokinetics
See Literature
Maxzide Interactions
Interactions
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Hyperkalemia more likely with ACE inhibitors. NSAIDs may cause renal failure. Hypokalemia with corticosteroids, ACTH, amphotericin B. Hypotension with CNS depressants. Potentiates other antihypertensives, nondepolarizing muscle relaxants. Antagonized by NSAIDs. Hyponatremia with sulfonylureas. Antagonizes folic acid. May block epinephrine. May interfere with parathyroid tests.
Maxzide Adverse Reactions
Adverse Reactions
Drowsiness, insomnia, muscle cramps, weakness, headache, GI disturbances, dizziness, orthostatic hypotension, hyperuricemia, impotence, renal stones, tachycardia, dyspnea, dry mouth, depression, anxiety, urine discoloration, elevated liver enzymes; HCTZ: increased risk for non-melanoma skin cancer.
Maxzide Clinical Trials
See Literature
Maxzide Note
Not Applicable
Maxzide Patient Counseling
See Literature
Maxzide Generic Name & Formulations
Legal Class
Rx
General Description
Triamterene 75mg, hydrochlorothiazide 50mg; scored tabs.
Pharmacological Class
Diuretic (K+ sparing) + (thiazide).
See Also
How Supplied
Tabs—100
Manufacturer
Maxzide Indications
Indications
Hypertension when normokalemia is essential.
Maxzide Dosage and Administration
Adult
1 tab daily.
Children
Not established.
Maxzide Contraindications
Contraindications
Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.
Maxzide Boxed Warnings
Boxed Warning
Risk of hyperkalemia.
Maxzide Warnings/Precautions
Warnings/Precautions
Diabetes. Acidosis predisposition. Electrolyte imbalance. Excessive diuresis. History of renal stones. Gout. Asthma. SLE. Surgery. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Elderly. Severely ill. Pregnancy. Nursing mothers: not recommended.
Maxzide Pharmacokinetics
See Literature
Maxzide Interactions
Interactions
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Hyperkalemia more likely with ACE inhibitors. NSAIDs may cause renal failure. Hypokalemia with corticosteroids, ACTH, amphotericin B. Hypotension with CNS depressants. Potentiates other antihypertensives, nondepolarizing muscle relaxants. Antagonized by NSAIDs. Hyponatremia with sulfonylureas. Antagonizes folic acid. May block epinephrine. May interfere with parathyroid tests.
Maxzide Adverse Reactions
Adverse Reactions
Drowsiness, insomnia, muscle cramps, weakness, headache, GI disturbances, dizziness, orthostatic hypotension, hyperuricemia, impotence, renal stones, tachycardia, dyspnea, dry mouth, depression, anxiety, urine discoloration, elevated liver enzymes; HCTZ: increased risk for non-melanoma skin cancer.
Maxzide Clinical Trials
See Literature
Maxzide Note
Not Applicable
Maxzide Patient Counseling
See Literature
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