Lovenox

For post-op dosing, assure hemostasis before starting. Knee: 30mg SC every 12hrs for 7–10 days; max 14 days (1^st dose 12–24hrs post-op). Hip: 30mg SC every 12hrs (1^st dose 12–24hrs post-op), or 40mg SC once daily (1^st dose 9–15hrs pre-op), for 7–10 days, then 40mg SC once daily for 3 weeks. Abdominal: 40mg SC once daily (1^st dose 2hrs pre-op) for 7–10 days; max 12 days. Severely restricted mobility due to acute illness: 40mg SC once daily for 6–11 days, max 14 days. DVT (without PE) outpatient: 1mg/kg every 12hrs SC; inpatient (with or without PE): 1mg/kg every 12hrs SC or 1.5mg/kg once daily SC; for both, start warfarin usually within 72hrs, continue enoxaparin at least 5 days and until INR is between 2–3 (usually 7 days; usual max 17 days). Unstable angina and non-Q-wave MI: 1mg/kg SC every 12hrs for at least 2 days, with aspirin 100–325mg once daily, until stable (usually 2–8 days; usual max 12.5 days). STEMI: 30mg IV bolus plus 1mg/kg SC dose, then 1mg/kg SC every 12hrs (max 100mg for 1^st 2 doses only, then 1mg/kg dosing for remaining doses), with aspirin 75–325mg once daily; usually for 8 days or until hospital discharge. Concomitant thrombolytics: give between 15mins before or 30mins after start of fibrinolytic therapy. PCI: if last enoxaparin dose given <8hrs before balloon inflation, no additional dose needed; >8hrs before balloon inflation, give 0.3mg/kg IV bolus. Elderly with STEMI: ≥75yrs: Do not give IV bolus; initially 0.75mg/kg SC every 12hrs (max 75mg for 1^st 2 doses only, then 0.75mg/kg dose for remaining doses). Severe renal impairment (CrCl<30mL/min) or low body weight: adjust dose (see full labeling).