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Lotensin Generic Name & Formulations
Legal Class
Rx
General Description
Benazepril (as HCl) 5mg, 10mg, 20mg, 40mg; tabs.
Pharmacological Class
ACE inhibitor.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Lotensin Indications
Indications
Hypertension.
Lotensin Dosage and Administration
Adult
If not on diuretic: initially 10mg once daily. Usual maintenance: 20–40mg daily in 1 or 2 divided doses; usual max 80mg/day. If on diuretic: initially 5mg once daily. If BP not controlled on benazepril alone, may add low dose diuretic. CrCl<30mL/min/1.73m2: initially 5mg daily; max 40mg/day.
Children
<6yrs or CrCl<30mL/min/1.73m2: not recommended. ≥6yrs: Initially 0.2mg/kg daily; usual max 0.6mg/kg/day (or 40mg/day). Prepare suspension if unable to swallow tablets or if calculated mg/kg dosage does not correspond to available tablet strengths (see full labeling).
Lotensin Contraindications
Contraindications
History of ACEI-associated or other angioedema. Concomitant neprilysin inhibitors (eg, sacubitril); do not administer benazepril within 36hrs of switching to or from sacubitril/valsartan. Concomitant aliskiren in patients with diabetes.
Lotensin Boxed Warnings
Boxed Warning
Fetal toxicity.
Lotensin Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion prior to initiation. CHF. Renal impairment. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Diabetes. Discontinue and treat if angioedema, laryngeal edema, jaundice or marked elevation of hepatic enzymes develop. Monitor BP, electrolytes, and renal function. Black patients may have higher rate of angioedema than non-black patients. Elderly. Neonates. Pregnancy: monitor. Nursing mothers.
Lotensin Pharmacokinetics
See Literature
Lotensin Interactions
Interactions
See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Avoid concomitant aliskiren in renal impairment (CrCl <60mL/min). Hyperkalemia with K+-sparing diuretics, K+ supplements, or K+-containing salt substitutes. May increase lithium levels. Potentiated by diuretics. May be antagonized by, and renal toxicity potentiated by, NSAIDs, including selective COX-2 inhibitors (monitor renal function periodically in elderly and/or volume depleted). Increased risk of angioedema with concomitant mTOR inhibitors (eg, temsirolimus, sirolimus, everolimus) or neprilysin inhibitors. Increased risk of hypoglycemia with insulins, oral hypoglycemic agents. Nitritoid reactions with concomitant injectable gold (eg, sodium aurothiomalate); rare.
Lotensin Adverse Reactions
Adverse Reactions
Headache, dizziness, fatigue, GI upset, cough, angioedema, orthostatic hypotension, hyperkalemia; rare: hepatic failure.
Lotensin Clinical Trials
See Literature
Lotensin Note
Not Applicable
Lotensin Patient Counseling
See Literature
