Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Lokelma Generic Name & Formulations
Legal Class
Rx
General Description
Sodium zirconium cyclosilicate 5g, 10g; per pkt; pwd for oral susp.
Pharmacological Class
Potassium binder.
How Supplied
Single-use packets—1, 11, 30
Manufacturer
Generic Availability
NO
Mechanism of Action
Sodium zirconium cyclosilicate is a non-absorbed zirconium silicate that preferentially captures potassium in exchange for hydrogen and sodium. Binding of potassium reduces the concentration of free potassium in the gastrointestinal lumen, thereby lowering serum potassium levels.
Lokelma Indications
Indications
Hyperkalemia.
Limitations of Use
Not as an emergency treatment for life-threatening hyperkalemia due to its delayed onset of action.
Lokelma Dosage and Administration
Adult
Give at least 2hrs before or 2hrs after other oral medications. Mix contents of packet into water. Initially 10g three times daily for up to 48hrs, then 10g once daily. Monitor and adjust dose in 5g increments based on serum potassium level at ≥1-week intervals to obtain desired target range. Usual maintenance range: 5g every other day to 15g daily. Hemodialysis: initially 5g once daily on non-dialysis days; consider 10g once daily if serum potassium >6.5mEq/L. Monitor and adjust dose based on pre-dialysis serum potassium level to obtain desired target range. Usual maintenance range: 5–15g daily.
Children
Not established.
Lokelma Contraindications
Not Applicable
Lokelma Boxed Warnings
Not Applicable
Lokelma Warnings/Precautions
Warnings/Precautions
Avoid in severe constipation, bowel obstruction or impaction, abnormal post-op bowel motility disorders. Monitor serum potassium levels. Monitor for edema esp. if heart failure or renal disease present. Advise patients to adjust dietary sodium, if appropriate. Increase diuretics dose as needed. Hemodialysis: increased risk of hypokalemia due to possible decreased oral intake or diarrhea; adjust dose based on potassium levels. May appear as an imaging agent during abdominal X-rays.
Lokelma Pharmacokinetics
Elimination
Fecal.
Lokelma Interactions
Interactions
May reduce absorption and efficacy of other oral medications; separate dosing by at least 2hrs.
Lokelma Adverse Reactions
Adverse Reactions
Edema.
Lokelma Clinical Trials
See Literature
Lokelma Note
Not Applicable
Lokelma Patient Counseling
See Literature
