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Lisinopril Generic Name & Formulations
Legal Class
Rx
General Description
Lisinopril 5mg, 10mg, 20mg; scored tabs.
Pharmacological Class
ACE inhibitor.
How Supplied
Contact supplier
Manufacturer
Lisinopril Indications
Indications
Heart failure inadequately controlled by diuretics +/or digitalis. Adjunct to other therapies within 24hrs post-MI in hemodynamically stable patients, to reduce mortality.
Lisinopril Dosage and Administration
Adult
CHF: initially 5mg once daily; if hyponatremia: initially 2.5mg once daily; may increase as tolerated up to max 40mg once daily; supervise closely. Reduce diuretic dosage before 1st dose (if possible) and observe until BP is stabilized. Post-MI: 5mg within 24hrs of onset of symptoms, then 5mg after 24hrs, then 10mg after 48hrs, then 10mg once daily for up to 6 weeks; if systolic BP ≤120mmHg at onset, start with 2.5mg daily for 3 days; or if systolic BP ≤100mmHg occurs, start with 5mg daily, then reduce to 2.5mg daily as needed; discontinue if prolonged hypotension (systolic BP ≤90mmHg for >1 hr) occurs. Renal impairment (CrCl 10–30mL/min): reduce initial dose to 50%; on hemodialysis or (CrCl <10mL/min): initially 2.5mg once daily.
Children
Not recommended.
Lisinopril Contraindications
Contraindications
History of ACEI-associated or other angioedema. Concomitant aliskiren in patients with diabetes. Concomitant neprilysin inhibitor (eg, sacubitril); do not give within 36hrs of switching to or from sacubitril/valsartan.
Lisinopril Boxed Warnings
Boxed Warning
Fetal toxicity.
Lisinopril Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Renal impairment. Dialysis (esp. high-flux membrane). Salt/volume depletion. Hypertrophic cardiomyopathy. CHF. Ischemic heart disease. Cerebrovascular disease. Post MI. Renal or aortic stenosis. Diabetes. Surgery. Discontinue and monitor if angioedema, laryngeal edema, marked elevations of liver enzymes, or jaundice occurs. Monitor BP, serum potassium, and renal function. Black patients may have higher risk of angioedema than non-Black patients. Elderly. Neonates. Pregnancy, nursing mothers: not recommended.
Lisinopril Pharmacokinetics
See Literature
Lisinopril Interactions
Interactions
See Contraindications. Increased risk of angioedema with concomitant neprilysin inhibitor or mTOR inhibitor (eg, temsirolimus, sirolimus, everolimus). Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. May cause hypotension or increased BUN with diuretics. May cause hyperkalemia with K+ sparing diuretics, K+ supplements, or K+ -containing salt substitutes; monitor frequently. May increase lithium levels; monitor. Antagonized by, and increased risk of renal failure with, NSAIDs including selective COX-2 inhibitors. Hypoglycemia with oral antidiabetics, insulin. Nitritoid reactions with concomitant injectable gold (sodium aurothiomalate); rare.
Lisinopril Adverse Reactions
Adverse Reactions
Dizziness, hypotension, headache, cough, chest pain, renal dysfunction, hyperkalemia, angioedema; rare: liver dysfunction, blood dyscrasias.
Lisinopril Clinical Trials
See Literature
Lisinopril Note
Notes
Formerly known under the brand name Prinivil.
Lisinopril Patient Counseling
See Literature
Lisinopril Generic Name & Formulations
Legal Class
Rx
General Description
Lisinopril 5mg, 10mg, 20mg; scored tabs.
Pharmacological Class
ACE inhibitor.
How Supplied
Contact supplier
Manufacturer
Lisinopril Indications
Indications
Hypertension.
Lisinopril Dosage and Administration
Adult
Initially and if not on diuretics: 10mg once daily. Usual range: 20–40mg once daily. Doses up to 80mg/day have been used. If BP not controlled by lisinopril alone, may add low-dose diuretic. If on diuretics: initially 5mg once daily. Renal impairment (CrCl 10–30mL/min): initially 5mg once daily; on hemodialysis or (CrCl <10mL/min): initially 2.5mg once daily.
Children
<6yrs or GFR <30mL/min/1.73m2: not recommended. ≥6yrs (GFR ≥30mL/min/1.73m2): initially 0.07mg/kg (max 5mg) once daily; usual max 0.61mg/kg (40mg) once daily.
Lisinopril Contraindications
Contraindications
History of ACEI-associated or other angioedema. Concomitant aliskiren in patients with diabetes. Concomitant neprilysin inhibitor (eg, sacubitril); do not give within 36hrs of switching to or from sacubitril/valsartan.
Lisinopril Boxed Warnings
Boxed Warning
Fetal toxicity.
Lisinopril Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Renal impairment. Dialysis (esp. high-flux membrane). Salt/volume depletion. Hypertrophic cardiomyopathy. CHF. Ischemic heart disease. Cerebrovascular disease. Post MI. Renal or aortic stenosis. Diabetes. Surgery. Discontinue and monitor if angioedema, laryngeal edema, marked elevations of liver enzymes, or jaundice occurs. Monitor BP, serum potassium, and renal function. Black patients may have higher risk of angioedema than non-Black patients. Elderly. Neonates. Pregnancy, nursing mothers: not recommended.
Lisinopril Pharmacokinetics
See Literature
Lisinopril Interactions
Interactions
See Contraindications. Increased risk of angioedema with concomitant neprilysin inhibitor or mTOR inhibitor (eg, temsirolimus, sirolimus, everolimus). Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. May cause hypotension or increased BUN with diuretics. May cause hyperkalemia with K+ sparing diuretics, K+ supplements, or K+ -containing salt substitutes; monitor frequently. May increase lithium levels; monitor. Antagonized by, and increased risk of renal failure with, NSAIDs including selective COX-2 inhibitors. Hypoglycemia with oral antidiabetics, insulin. Nitritoid reactions with concomitant injectable gold (sodium aurothiomalate); rare.
Lisinopril Adverse Reactions
Adverse Reactions
Dizziness, hypotension, headache, cough, chest pain, renal dysfunction, hyperkalemia, angioedema; rare: liver dysfunction, blood dyscrasias.
Lisinopril Clinical Trials
See Literature
Lisinopril Note
Notes
Formerly known under the brand name Prinivil.
Lisinopril Patient Counseling
See Literature
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