Lasix

Concomitant chloral hydrate: not recommended. Concomitant acetylsalicylic acid may reduce creatinine clearance. Digitalis, lithium, salicylate toxicity. Alcohol, CNS depressants may increase orthostatic hypotension. Severe hypotension and renal function deterioration/failure with ACEIs or ARBs; may need to interrupt or reduce dose. Antagonized by indomethacin, phenytoin. Hypokalemia with corticosteroids, ACTH, large amounts of licorice, prolonged laxatives. Increased risk of cephalosporin-induced nephrotoxicity and radiocontrast nephropathy. Increased risk of gouty arthritis and impairment of renal urate excretion with cyclosporine. Antagonizes tubocurarine, norepinephrine. Potentiates antihypertensives, succinylcholine, ganglionic or peripheral adrenergic blocking drugs. Ototoxicity with aminoglycosides, ethacrynic acid. Ototoxicity, nephrotoxicity with cisplatin (give lower doses of furosemide with positive fluid balance). Separate sucralfate dosing by at least two hours. Antagonized by, and potentiates, methotrexate and others that undergo renal tubular secretion. High doses (>80mg) may affect thyroid hormone levels. Increased BUN, serum creatinine, serum potassium levels, and weight gain may develop with NSAIDs.

Concomitant chloral hydrate: not recommended. Concomitant acetylsalicylic acid may reduce creatinine clearance. Digitalis, lithium, salicylate toxicity. Alcohol, CNS depressants may increase orthostatic hypotension. Severe hypotension and renal function deterioration/failure with ACEIs or ARBs; may need to interrupt or reduce dose. Antagonized by indomethacin, phenytoin. Hypokalemia with corticosteroids, ACTH, large amounts of licorice, prolonged laxatives. Increased risk of cephalosporin-induced nephrotoxicity and radiocontrast nephropathy. Increased risk of gouty arthritis and impairment of renal urate excretion with cyclosporine. Antagonizes tubocurarine, norepinephrine. Potentiates antihypertensives, succinylcholine, ganglionic or peripheral adrenergic blocking drugs. Ototoxicity with aminoglycosides, ethacrynic acid. Ototoxicity, nephrotoxicity with cisplatin (give lower doses of furosemide with positive fluid balance). Separate sucralfate dosing by at least two hours. Antagonized by, and potentiates, methotrexate and others that undergo renal tubular secretion. High doses (>80mg) may affect thyroid hormone levels. Increased BUN, serum creatinine, serum potassium levels, and weight gain may develop with NSAIDs.