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Labetalol Hcl Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Labetalol HCl 100mg, 200mg, 300mg; scored tabs.
Pharmacological Class
Noncardioselective beta-blocker/alpha-1 blocker.
How Supplied
Contact supplier.
Manufacturer
Labetalol Hcl Tablets Indications
Indications
Hypertension.
Labetalol Hcl Tablets Dosage and Administration
Adult
Individualize. Initially 100mg twice daily. Titrate at 2–3 day intervals in increments of 100mg twice daily. Usual maintenance: 200–400mg twice daily; max 2.4g/day.
Children
Not recommended.
Labetalol Hcl Tablets Contraindications
Contraindications
Asthma. 2nd- or 3rd-degree AV block. Overt cardiac failure. Cardiogenic shock. Severe bradycardia, other conditions associated with prolonged or severe hypotension.
Labetalol Hcl Tablets Boxed Warnings
Not Applicable
Labetalol Hcl Tablets Warnings/Precautions
Warnings/Precautions
History of heart failure; withdraw gradually if cardiac failure continues despite adequate digitalization and diuretic. Monitor hepatic function; discontinue at first sign of liver injury. COPD. Pheochromocytoma. Diabetes. Surgery. Avoid abrupt cessation (ischemic heart disease may be exacerbated). Elderly. Pregnancy (Cat.C). Nursing mothers.
Labetalol Hcl Tablets Pharmacokinetics
See Literature
Labetalol Hcl Tablets Interactions
Interactions
Caution with verapamil. Potentiates hypotension with nitroglycerin. May block epinephrine, β-agonist bronchodilators. Adjust antidiabetic medication. Potentiated by cimetidine. Tremor with tricyclic antidepressants. Synergism with halothane; do not use high concentrations.
Labetalol Hcl Tablets Adverse Reactions
Adverse Reactions
Dizziness, GI upset, fatigue, nasal stuffiness, ejaculation failure, headache, dyspnea, vertigo, rash, orthostatic hypotension, edema, heart failure, bronchospasm, jaundice.
Labetalol Hcl Tablets Clinical Trials
See Literature
Labetalol Hcl Tablets Note
Notes
Formerly known under the brand names Normodyne, Trandate.
Labetalol Hcl Tablets Patient Counseling
See Literature
