Labetalol HCl Injection Dosage & Rx Info

Labetalol Hcl Injection Generic Name & Formulations

Legal Class

General Description

Labetalol HCl 5mg/mL; soln for IV inj and infusion after dilution; contains parabens.

Pharmacological Class

Noncardioselective beta-blocker/alpha-1 blocker.

How Supplied

Contact supplier.

Manufacturer

Various generic manufacturers

Mechanism of Action

Labetalol combines both selective, competitive alpha₁-adrenergic blocking and nonselective, competitive beta-adrenergic blocking activity in a single substance. Beta₂-agonist activity has been demonstrated in animals with minimal beta1-agonist (ISA) activity detected. In animals, at doses greater than those required for alpha- or beta-adrenergic blockade, a membrane-stabilizing effect has been demonstrated.

Labetalol Hcl Injection Indications

Indications

Severe hypertension.

Labetalol Hcl Injection Dosage and Administration

Adult

Individualize. Maintain supine position; monitor BP. Repeated IV inj: 20mg over 2 minutes, may give additional 40mg or 80mg at 10 minute intervals up to max total dose of 300mg or until desired supine BP. Slow continuous infusion: 2mg/min (see literature).

Children

Not recommended.

Labetalol Hcl Injection Contraindications

Contraindications

Bronchial asthma. Overt cardiac failure. 2^nd- or 3^rd- degree AV block. Cardiogenic shock. Severe bradycardia. Other conditions associated with severe and prolonged hypotension. History of obstructive airway disease (eg, asthma).

Labetalol Hcl Injection Boxed Warnings

Not Applicable

Labetalol Hcl Injection Warnings/Precautions

Warnings/Precautions

Ischemic heart disease or failure. Monitor hepatic function: discontinue at first sign of liver injury. If signs of cardiac failure, treat with digitalis or diuretic, discontinue if failure continues. Increased risk for hypoglycemia esp. in diabetics or those who are fasting (eg, surgery, not eating regularly, or vomiting). COPD. Pheochromocytoma. Diabetes. Surgery. Avoid abrupt cessation. Elderly. Pregnancy. Nursing mothers.

Labetalol Hcl Injection Pharmacokinetics

Metabolism

Hepatic.

Elimination

Renal, fecal. Half-life: ~5.5 hours.

Labetalol Hcl Injection Interactions

Interactions

Caution with verapamil. Potentiates hypotension with nitroglycerin. May blunt effects of epinephrine, β-agonist bronchodilators. Avoid alkaline drugs (eg, furosemide) administration in same infusion line. Adjust antidiabetic medication. Potentiated by cimetidine and halothane. Tremor with tricyclic antidepressants. May cause false positive urine test for amphetamine.

Labetalol Hcl Injection Adverse Reactions

Adverse Reactions

Symptomatic postural hypotension, GI upset, dizziness, increased BUN and serum creatinine, paresthesias, sweating, somnolence, flushing, ventricular arrhythmia, vertigo, pruritus.

Labetalol Hcl Injection Clinical Trials

See Literature

Labetalol Hcl Injection Note

Notes

Formerly known under the brand names Normodyne, Trandate.

Labetalol Hcl Injection Patient Counseling