Jardiance

Correct volume depletion before initiating. Increased risk for volume depletion or hypotension in those with renal impairment (eGFR <60mL/min/1.73m²), elderly, or on loop diuretics. Assess volume status and renal function prior to initiation; monitor during therapy. Assess for ketoacidosis in presence of signs/symptoms of metabolic acidosis, regardless of blood glucose levels; discontinue if suspected; evaluate and treat if confirmed. Monitor for resolution of ketoacidosis before restarting. Withhold (at least 3 days), if possible, prior to major surgery or procedures associated with prolonged fasting. Necrotizing fasciitis of the perineum (Fournier's gangrene); discontinue and treat immediately if suspected; use alternative antidiabetic. Increased risk for genital mycotic infections or UTIs; monitor and treat appropriately. Increased risk for lower limb amputations (esp. history of diabetic foot, peripheral vascular disease, prior amputation, diabetes). Monitor for foot infection (including osteomyelitis), new pain or tenderness, sores or ulcers in lower limbs; treat appropriately. Discontinue if hypersensitivity reaction occurs; treat promptly and monitor until resolve. Elderly. Pregnancy (during 2^nd & 3^rd trimesters), nursing mothers: not recommended.

Correct volume depletion before initiating. Increased risk for volume depletion or hypotension in those with renal impairment (eGFR <60mL/min/1.73m²), elderly, or on loop diuretics. Assess volume status and renal function prior to initiation; monitor during therapy. Assess for ketoacidosis in presence of signs/symptoms of metabolic acidosis, regardless of blood glucose levels; discontinue if suspected; evaluate and treat if confirmed. Monitor for resolution of ketoacidosis before restarting. Withhold (at least 3 days), if possible, prior to major surgery or procedures associated with prolonged fasting. Necrotizing fasciitis of the perineum (Fournier's gangrene); discontinue and treat immediately if suspected; use alternative antidiabetic. Increased risk for genital mycotic infections or UTIs; monitor and treat appropriately. Increased risk for lower limb amputations (esp. history of diabetic foot, peripheral vascular disease, prior amputation, diabetes). Monitor for foot infection (including osteomyelitis), new pain or tenderness, sores or ulcers in lower limbs; treat appropriately. Discontinue if hypersensitivity reaction occurs; treat promptly and monitor until resolve. Elderly. Pregnancy (during 2^nd & 3^rd trimesters), nursing mothers: not recommended.

Correct volume depletion before initiating. Increased risk for volume depletion or hypotension in those with renal impairment (eGFR <60mL/min/1.73m²), elderly, or on loop diuretics. Assess volume status and renal function prior to initiation; monitor during therapy. Assess for ketoacidosis in presence of signs/symptoms of metabolic acidosis, regardless of blood glucose levels; discontinue if suspected; evaluate and treat if confirmed. Monitor for resolution of ketoacidosis before restarting. Withhold (at least 3 days), if possible, prior to major surgery or procedures associated with prolonged fasting. Necrotizing fasciitis of the perineum (Fournier's gangrene); discontinue and treat immediately if suspected; use alternative antidiabetic. Increased risk for genital mycotic infections or UTIs; monitor and treat appropriately. Increased risk for lower limb amputations (esp. history of diabetic foot, peripheral vascular disease, prior amputation, diabetes). Monitor for foot infection (including osteomyelitis), new pain or tenderness, sores or ulcers in lower limbs; treat appropriately. Discontinue if hypersensitivity reaction occurs; treat promptly and monitor until resolve. Elderly. Pregnancy (during 2^nd & 3^rd trimesters), nursing mothers: not recommended.