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Isosorbide Dinitrate Generic Name & Formulations
Legal Class
Rx
General Description
Isosorbide dinitrate 2.5mg, 5mg; sublingual tabs.
Pharmacological Class
Nitrate.
See Also
How Supplied
Sublingual—contact supplier; Titradose—100
Manufacturer
Generic Availability
Titradose (YES)
Isosorbide Dinitrate Indications
Indications
Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina.
Isosorbide Dinitrate Dosage and Administration
Adult
2.5–5mg sublingually 15 mins before activity; allow a daily dose-free interval of at least 14hrs.
Children
Not established.
Isosorbide Dinitrate Contraindications
Contraindications
Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.
Isosorbide Dinitrate Boxed Warnings
Not Applicable
Isosorbide Dinitrate Warnings/Precautions
Warnings/Precautions
Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.
Isosorbide Dinitrate Pharmacokinetics
See Literature
Isosorbide Dinitrate Interactions
Interactions
See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.
Isosorbide Dinitrate Adverse Reactions
Adverse Reactions
Headache, orthostatic hypotension, paradoxical bradycardia.
Isosorbide Dinitrate Clinical Trials
See Literature
Isosorbide Dinitrate Note
Notes
Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.
Isosorbide Dinitrate Patient Counseling
See Literature
