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Isordil Titradose Generic Name & Formulations
Legal Class
Rx
General Description
Isosorbide dinitrate 5mg, 40mg; scored oral tabs.
Pharmacological Class
Nitrate.
See Also
How Supplied
Sublingual—contact supplier; Titradose—100
Manufacturer
Generic Availability
Titradose (YES)
Isordil Titradose Indications
Indications
Prophylaxis of angina. Not for acute attacks.
Isordil Titradose Dosage and Administration
Adult
Initially 5–20mg 2–3 times per day. Maintenance: 10–40mg 2–3 times per day; allow a daily dose-free interval of at least 14hrs.
Children
Not established.
Isordil Titradose Contraindications
Contraindications
Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.
Isordil Titradose Boxed Warnings
Not Applicable
Isordil Titradose Warnings/Precautions
Warnings/Precautions
Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.
Isordil Titradose Pharmacokinetics
See Literature
Isordil Titradose Interactions
Interactions
See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.
Isordil Titradose Adverse Reactions
Adverse Reactions
Headache, orthostatic hypotension, paradoxical bradycardia.
Isordil Titradose Clinical Trials
See Literature
Isordil Titradose Note
Notes
Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.
Isordil Titradose Patient Counseling
See Literature
