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Innopran Xl Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 80mg, 120mg; ext-rel caps.
Pharmacological Class
Noncardioselective beta-blocker.
How Supplied
Caps—30
Manufacturer
Generic Availability
NO
Mechanism of Action
Propranolol, a nonselective, β-adrenergic receptor blocker, has no autonomic nervous system activity. Its antihypertensive effect may be due to: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain.
Innopran Xl Indications
Indications
Hypertension.
Innopran Xl Dosage and Administration
Adult
≥18yrs: Take once daily at bedtime (10PM). Take consistently with regard to food. Initially 80mg/day, may increase to 120mg/day.
Children
<18yrs: not established.
Innopran Xl Contraindications
Contraindications
Cardiogenic shock. Sinus bradycardia, sick sinus syndrome and >1st -degree AV block unless paced. Asthma.
Innopran Xl Boxed Warnings
Not Applicable
Innopran Xl Warnings/Precautions
Warnings/Precautions
Risk of cardiac ischemia after abrupt discontinuation. Bronchospastic disease. Heart failure. Cardiogenic shock. Wolff-Parkinson-White syndrome. Diabetes. May mask signs and increase risk for hypoglycemia. Hyperthyroidism. Surgery. SLE. Musculoskeletal disease. Renal or hepatic impairment. Avoid abrupt cessation. Elderly. Neonates. Pregnancy. Nursing mothers.
Innopran Xl Pharmacokinetics
Distribution
Volume of distribution: ~4 L. Plasma protein bound: ~90%.
Elimination
Renal. Half-life: ~8 hours.
Innopran Xl Interactions
Interactions
Potentiated by substrates or inhibitors of CYP2D6 (eg, amiodarone, cimetidine, fluoxetine, paroxetine, quinidine, ritonavir), CYP1A2 (eg, imipramine, ciprofloxacin, theophylline, zolmitriptan), or CYP2C19 (eg, fluconazole), CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, MAOIs, tricyclic antidepressants, alcohol. Antagonized by NSAIDs, aluminum hydroxide; bile acid resins (eg, cholestyramine, colestipol); smoking, chronic alcohol use, and other inducers of CYP2D6, 1A2, or 2C19. Potentiates amiodarone, chlorpromazine, diazepam, lidocaine, bupivacaine, mepivacaine, propafenone, theophylline, thioridazine, warfarin, rizatriptan, zolmitriptan. May increase cardiac effects of calcium channel blockers, digitalis, disopyramide, lidocaine. Bradycardia with catecholamine-depleting drugs. Increased orthostatic hypotension with α-blockers. Caution when withdrawing clonidine. Increased bronchial hyperreactivity with ACEIs. May interfere with glaucoma or thyroid tests. May block epinephrine.
Innopran Xl Adverse Reactions
Adverse Reactions
Fatigue, dizziness, constipation, bradycardia, heart failure/block, GI upset, bronchospasm, agranulocytosis, myopathy, myotonia, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria); rare: SLE, alopecia, impotence.
Innopran Xl Clinical Trials
See Literature
Innopran Xl Note
Not Applicable
Innopran Xl Patient Counseling
See Literature
