Inderal La

— THERAPEUTIC CATEGORIES —
  • Angina
  • Hypertension
  • Migraine and headache
PAGE CONTENTS
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  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Inderal La Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Propranolol HCl 60mg, 80mg, 120mg, 160mg; sust-rel caps.

    Pharmacological Class

    Beta-blocker.

    See Also

    How Supplied

    Tabs—contact supplier; LA—100

    Manufacturer

    ANI Pharmaceuticals, Inc.

    Mechanism of Action

    Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction.

    Inderal La Indications

    Indications

    Long-term management of angina. Hypertrophic subaortic stenosis.

    Inderal La Dosage and Administration

    Adult

    Angina: Initially 80mg once daily. May increase at 3–7 day intervals; max 320mg daily. Stenosis: 80–160mg once daily.

    Children

    Not recommended.

    Inderal La Contraindications

    Contraindications

    Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

    Inderal La Boxed Warnings

    Not Applicable

    Inderal La Warnings/Precautions

    Warnings/Precautions

    CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. May mask signs and increase risk for hypoglycemia. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

    Inderal La Pharmacokinetics

    Absorption

    Peak blood levels occur at about 6 hours post-dosing.

    Distribution

    Plasma protein bound: ~90%. Volume of distribution: ~4 L/kg. Propranolol crosses the blood-brain barrier and the placenta, ad is distributed into breast milk.

    Metabolism

    Hepatic (aromatic hydroxylation, N-dealkylation, glucuronidation).

    Elimination

    Renal. Half-life: 10hrs.

    Inderal La Interactions

    Interactions

    Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.

    Inderal La Adverse Reactions

    Adverse Reactions

    Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.

    Inderal La Clinical Trials

    See Literature

    Inderal La Note

    Not Applicable

    Inderal La Patient Counseling

    See Literature

    Inderal La Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Propranolol HCl 60mg, 80mg, 120mg, 160mg; sust-rel caps.

    Pharmacological Class

    Beta-blocker.

    See Also

    How Supplied

    Tabs—contact supplier; LA—100

    Manufacturer

    ANI Pharmaceuticals, Inc.

    Mechanism of Action

    Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. Its antihypertensive effect is thought to include: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain.

    Inderal La Indications

    Indications

    Hypertension. Adjunct in pheochromocytoma.

    Inderal La Dosage and Administration

    Adult

    Initially 80mg daily. Usual maintenance: 120–160mg daily; max 640mg daily.

    Children

    Not recommended.

    Inderal La Contraindications

    Contraindications

    Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

    Inderal La Boxed Warnings

    Not Applicable

    Inderal La Warnings/Precautions

    Warnings/Precautions

    CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. May mask signs and increase risk for hypoglycemia. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

    Inderal La Pharmacokinetics

    Absorption

    Peak plasma concentrations occur about 1–4 hours post-dose.

    Distribution

    Plasma protein bound: ~90%. Volume of distribution: ~4 L/kg. Propranolol crosses the blood-brain barrier and the placenta, ad is distributed into breast milk.

    Metabolism

    Hepatic (aromatic hydroxylation, N-dealkylation, glucuronidation).

    Elimination

    Renal. Half-life: 3–6hrs.

    Inderal La Interactions

    Interactions

    Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.

    Inderal La Adverse Reactions

    Adverse Reactions

    Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.

    Inderal La Clinical Trials

    See Literature

    Inderal La Note

    Not Applicable

    Inderal La Patient Counseling

    See Literature

    Inderal La Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Propranolol HCl 60mg, 80mg, 120mg, 160mg; sust-rel caps.

    Pharmacological Class

    Beta-blocker.

    See Also

    How Supplied

    Tabs—contact supplier; LA—100

    Manufacturer

    ANI Pharmaceuticals, Inc.

    Mechanism of Action

    Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. The mechanism of the antimigraine effect has not been established. β-adrenergic receptors have been demonstrated in the pial vessels of the brain.

    Inderal La Indications

    Indications

    Migraine prophylaxis.

    Inderal La Dosage and Administration

    Adult

    Initially 80mg daily. Usual range: 160–240mg daily. Discontinue if poor result after 4–6 weeks.

    Children

    Not recommended.

    Inderal La Contraindications

    Contraindications

    Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

    Inderal La Boxed Warnings

    Not Applicable

    Inderal La Warnings/Precautions

    Warnings/Precautions

    CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. May mask signs and increase risk for hypoglycemia. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

    Inderal La Pharmacokinetics

    Absorption

    Peak plasma concentrations occur about 1–4 hours post-dose.

    Distribution

    Plasma protein bound: ~90%. Volume of distribution: ~4 L/kg. Propranolol crosses the blood-brain barrier and the placenta, ad is distributed into breast milk.

    Metabolism

    Hepatic (aromatic hydroxylation, N-dealkylation, glucuronidation).

    Elimination

    Renal. Half-life: 3–6hrs.

    Inderal La Interactions

    Interactions

    Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.

    Inderal La Adverse Reactions

    Adverse Reactions

    Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.

    Inderal La Clinical Trials

    See Literature

    Inderal La Note

    Not Applicable

    Inderal La Patient Counseling

    See Literature

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