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Hydrochlorothiazide Generic Name & Formulations
Legal Class
Rx
General Description
Hydrochlorothiazide 12.5mg, 25mg+, 50mg+; tabs; +scored
Pharmacological Class
Diuretic (thiazide).
How Supplied
Contact supplier
Manufacturer
Hydrochlorothiazide Indications
Indications
Edema.
Hydrochlorothiazide Dosage and Administration
Adult
25–100mg daily in single or divided doses; may give on intermittent schedule (every other day or 3–5 days/wk).
Children
<6mos: up to 3mg/kg/day in 2 divided doses. ≥6mos: 1–2mg/kg/day in 1–2 divided doses. Max (<2yrs): 37.5mg/day; (2–12yrs): 100mg/day.
Hydrochlorothiazide Contraindications
Contraindications
Anuria. Sulfonamide allergy.
Hydrochlorothiazide Boxed Warnings
Not Applicable
Hydrochlorothiazide Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). K+ supplements or K+ sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Hydrochlorothiazide Pharmacokinetics
See Literature
Hydrochlorothiazide Interactions
Interactions
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. NSAIDs may cause renal failure. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Hyperglycemia, hyperuricemia more likely with diazoxide. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests.
Hydrochlorothiazide Adverse Reactions
Adverse Reactions
Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.
Hydrochlorothiazide Clinical Trials
See Literature
Hydrochlorothiazide Note
Notes
Formerly known under the brand names Esidrix, Hydro-D, Hydrodiuril, Microzide.
Hydrochlorothiazide Patient Counseling
See Literature
Hydrochlorothiazide Generic Name & Formulations
Legal Class
Rx
General Description
Hydrochlorothiazide 12.5mg, 25mg+, 50mg+; tabs; +scored
Pharmacological Class
Diuretic (thiazide).
How Supplied
Contact supplier
Manufacturer
Hydrochlorothiazide Indications
Indications
Hypertension.
Hydrochlorothiazide Dosage and Administration
Adult
Initially 25mg once daily; usual max 50mg/day in 1–2 divided doses.
Children
<6mos: up to 3mg/kg/day in 2 divided doses. ≥6mos: 1–2mg/kg/day in 1–2 divided doses. Max (<2yrs): 37.5mg/day; (2–12yrs): 100mg/day.
Hydrochlorothiazide Contraindications
Contraindications
Anuria. Sulfonamide allergy.
Hydrochlorothiazide Boxed Warnings
Not Applicable
Hydrochlorothiazide Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). K+ supplements or K+ sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Hydrochlorothiazide Pharmacokinetics
See Literature
Hydrochlorothiazide Interactions
Interactions
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. NSAIDs may cause renal failure. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Hyperglycemia, hyperuricemia more likely with diazoxide. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests.
Hydrochlorothiazide Adverse Reactions
Adverse Reactions
Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.
Hydrochlorothiazide Clinical Trials
See Literature
Hydrochlorothiazide Note
Notes
Formerly known under the brand names Esidrix, Hydro-D, Hydrodiuril, Microzide.
Hydrochlorothiazide Patient Counseling
See Literature
