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Giapreza Generic Name & Formulations
Legal Class
Rx
General Description
Angiotensin II 2.5mg/mL; per vial; soln for IV infusion after dilution.
Pharmacological Class
Vasoconstrictor.
How Supplied
Single-dose vial (1mL, 2mL)—1
Manufacturer
Generic Availability
NO
Giapreza Indications
Indications
To increase blood pressure in septic or other distributive shock.
Giapreza Dosage and Administration
Adult
Give by IV infusion. Initially 20ng/kg/min. May titrate every 5mins by increments of up to 15ng/kg/min as needed based on BP response; max 80ng/kg/min during first 3hrs of treatment. Maintenance dose: max 40ng/kg/min. Doses as low as 1.25ng/kg/min may be used. Once sufficiently improved, down-titrate every 5–15mins by increments of up to 15ng/kg/min based on BP.
Children
Not established.
Giapreza Contraindications
Not Applicable
Giapreza Boxed Warnings
Not Applicable
Giapreza Warnings/Precautions
Warnings/Precautions
Risk of thrombosis. Use concurrent VTE prophylaxis. Pregnancy. Nursing mothers.
Giapreza Pharmacokinetics
See Literature
Giapreza Interactions
Interactions
Concomitant ACE inhibitors may increase response. Concomitant ARBs may decrease response.
Giapreza Adverse Reactions
Adverse Reactions
Thromboembolic events (eg, deep vein thrombosis), thrombocytopenia, tachycardia, fungal infection, delirium, acidosis, hyperglycemia, peripheral ischemia.
Giapreza Clinical Trials
See Literature
Giapreza Note
Not Applicable
Giapreza Patient Counseling
See Literature
