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Fosinopril/hydrochlorothiazide Generic Name & Formulations
Legal Class
Rx
General Description
Fosinopril sodium, hydrochlorothiazide; 10mg/12.5mg, 20mg/12.5mg; tabs.
Pharmacological Class
ACE inhibitor + diuretic (thiazide).
How Supplied
Contact supplier.
Manufacturer
Fosinopril/hydrochlorothiazide Indications
Indications
Hypertension. Not for initial therapy.
Fosinopril/hydrochlorothiazide Dosage and Administration
Adult
Give once daily. Usual range: fosinopril: 10–20mg; HCTZ: 12.5–50mg. Severe renal impairment (CrCl<30mL/min): not recommended.
Children
Not recommended.
Fosinopril/hydrochlorothiazide Contraindications
Contraindications
Anuria. Hypersensitivity to ACE inhibitors, sulfonamide-derived drugs.
Fosinopril/hydrochlorothiazide Boxed Warnings
Not Applicable
Fosinopril/hydrochlorothiazide Warnings/Precautions
Warnings/Precautions
Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Salt/volume depletion; correct before initiating therapy. Renal or hepatic impairment. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Diabetes. Gout. SLE. Monitor WBCs in renal or collagen vascular disease. Monitor electrolytes, BUN (if high). Pregnancy (Cat.C in 1st trimester; Cat.D in 2nd and 3rd trimester). Nursing mothers: not recommended.
Fosinopril/hydrochlorothiazide Pharmacokinetics
See Literature
Fosinopril/hydrochlorothiazide Interactions
Interactions
Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Antagonized by NSAIDs. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements. May antagonize norepinephrine, methenamine. May potentiate nondepolarizing muscle relaxants. Adjust antidiabetic, antigout medications. ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid tests. Nitritoid reactions with injectable gold.
Fosinopril/hydrochlorothiazide Adverse Reactions
Adverse Reactions
Headache, cough, fatigue; hyperkalemia, orthostatic hypotension, angioedema (discontinue if occurs).
Fosinopril/hydrochlorothiazide Clinical Trials
See Literature
Fosinopril/hydrochlorothiazide Note
Notes
Formerly known under the brand name Monopril HCT.
Fosinopril/hydrochlorothiazide Patient Counseling
See Literature
