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Flolan Generic Name & Formulations
Legal Class
Rx
General Description
Epoprostenol (as sodium) 0.5mg, 1.5mg; per vial; pwd for IV infusion after reconstitution.
Pharmacological Class
Prostacyclin analogue.
How Supplied
Vial—1 (w. diluent)
Manufacturer
Generic Availability
YES
Flolan Indications
Indications
Pulmonary arterial hypertension (PAH) (WHO Group I) in patients with NYHA Class III or IV symptoms, to improve exercise ability.
Flolan Dosage and Administration
Adult
Give by continuous chronic IV infusion through a central venous catheter. Initially 2ng/kg/min; increase in increments of 1–2ng/kg/min at ≥15min intervals based on response. Decrease dose gradually in 2ng/kg/min decrements at ≥15min intervals until dose-limiting effects resolve.
Children
Not established.
Flolan Contraindications
Contraindications
Heart failure due to reduced left ventricular ejection fraction.
Flolan Boxed Warnings
Not Applicable
Flolan Warnings/Precautions
Warnings/Precautions
Avoid abrupt withdrawal or large dose reductions (may cause rebound pulmonary hypertension). Discontinue if pulmonary edema occurs; do not restart. Increased risk for hemorrhagic complications. Monitor BP and symptoms of vasodilation during initiation and after dose changes. Pregnancy. Nursing mothers.
Flolan Pharmacokinetics
See Literature
Flolan Interactions
Interactions
Hypotensive effects may be potentiated by diuretics, antihypertensive agents, other vasodilators. Increased risk of bleeding with anticoagulants, antiplatelets.
Flolan Adverse Reactions
Adverse Reactions
Dizziness, jaw pain, headache, musculoskeletal pain, nausea, vomiting, flushing.
Flolan Clinical Trials
See Literature
Flolan Note
Not Applicable
Flolan Patient Counseling
See Literature
