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Felodipine Generic Name & Formulations
Legal Class
Rx
General Description
Felodipine 2.5mg, 5mg, 10mg; ext rel tabs.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
How Supplied
Contact supplier.
Manufacturer
Felodipine Indications
Indications
Hypertension.
Felodipine Dosage and Administration
Adult
Take without food or with a light meal. Do not crush or chew. Initially 5mg once daily. Range 2.5–10mg once daily. Adjust at 2 week intervals; max 10mg daily. Elderly or hepatic impairment: initially 2.5mg once daily.
Children
Not established.
Felodipine Contraindications
Not Applicable
Felodipine Boxed Warnings
Not Applicable
Felodipine Warnings/Precautions
Warnings/Precautions
Heart failure. Hepatic impairment. Maintain good dental hygiene. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Felodipine Pharmacokinetics
See Literature
Felodipine Interactions
Interactions
May increase metoprolol, tacrolimus levels. Potentiated by cimetidine. Increased bioavailability with grapefruit juice. Levels decreased with long-term anticonvulsants (eg, carbamazepine, phenytoin, phenobarbital), consider alternate antihypertensive therapy.
Felodipine Adverse Reactions
Adverse Reactions
Peripheral edema, headache, flushing, dizziness, respiratory symptoms, weakness, cough, GI upset, gynecomastia; hypotension, tachycardia, syncope, MI, angina, gingival hyperplasia (rare).
Felodipine Clinical Trials
See Literature
Felodipine Note
Notes
Formerly known under the brand name Plendil.
Felodipine Patient Counseling
See Literature
