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Eptifibatide Generic Name & Formulations
Legal Class
Rx
General Description
Eptifibatide 0.75mg/mL, 2mg/mL; soln for IV inj.
Pharmacological Class
Antiplatelet.
How Supplied
Contact supplier.
Manufacturer
Eptifibatide Indications
Indications
For acute coronary syndrome, including patients who are to be managed medically and those undergoing percutaneous coronary intervention (PCI), including those undergoing intracoronary stenting.
Eptifibatide Dosage and Administration
Adult
See full labeling. Use in combination with aspirin and heparin. ACS: 180micrograms/kg IV bolus, followed by a continuous IV infusion of 2micrograms/kg/min until discharge or CABG surgery, up to 72hrs. If PCI planned, continue infusion until discharge, or for up to 18–24hrs after procedure, whichever comes first, allowing up to 96hrs of therapy. PCI: 180micrograms/kg IV bolus followed by 2micrograms/kg/min infusion; repeat 180micrograms/kg IV bolus 10mins after the 1st bolus; continue infusion until discharge, or for up to 18–24hrs, whichever comes first, minimum 12hr-infusion recommended. CrCl <50mL/min: reduce infusion rate to 1microgram/kg/min.
Children
Not recommended.
Eptifibatide Contraindications
Contraindications
Bleeding diathesis or active abnormal bleeding within previous 30 days. Severe uncontrolled hypertension. Major surgery within previous 6 weeks. History of stroke within 30 days or any history of hemorrhagic stroke. Concomitant parenteral GP IIb/IIIa inhibitors. Renal dialysis.
Eptifibatide Boxed Warnings
Not Applicable
Eptifibatide Warnings/Precautions
Warnings/Precautions
See full labeling. Discontinue if uncontrolled bleeding occurs. Platelet count <100,000/mm3. Properly care for femoral artery access site to minimize bleeding. Minimize other arterial and venous punctures, IM inj, catheter use, intubation, NG tubes, to lower bleeding risk; avoid use of non-compressible IV access sites. Do baseline platelet counts, hemoglobin, hematocrit, others and monitor during therapy (see full labeling). Discontinue if confirmed thrombocytopenia occurs. Renal insufficiency. Pregnancy (Cat.B). Nursing mothers: not recommended.
Eptifibatide Pharmacokinetics
See Literature
Eptifibatide Interactions
Interactions
Antiplatelet effects may be potentiated by thrombolytics, oral anticoagulants, NSAIDs, and dipyridamole.
Eptifibatide Adverse Reactions
Adverse Reactions
Bleeding, intracranial hemorrhage, stroke, thrombocytopenia, hypersensitivity reactions, hypotension.
Eptifibatide Clinical Trials
See Literature
Eptifibatide Note
Notes
Formerly known under the brand name Integrilin.
Eptifibatide Patient Counseling
See Literature
