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Enalaprilat Injection Generic Name & Formulations
Legal Class
Rx
General Description
Enalaprilat 1.25mg/mL; soln for IV inj.
Pharmacological Class
ACE inhibitor.
How Supplied
Contact supplier.
Manufacturer
Enalaprilat Injection Indications
Indications
To reduce blood pressure when oral therapy is not practical.
Enalaprilat Injection Dosage and Administration
Adult
Give by IV inj over 5 minutes (administer over a longer period of time [up to 1 hour] in patients at risk for excessive hypotension). 1.25mg every 6 hours; max 20mg/day. Concomitant diuretics or CrCl≤30mL/min: initially 0.625mg; if inadequate response after 1 hour, may give additional 0.625mg dose; additional doses of 1.25mg may be given every 6 hours thereafter.
Children
Not recommended.
Enalaprilat Injection Contraindications
Contraindications
History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters).
Enalaprilat Injection Boxed Warnings
Not Applicable
Enalaprilat Injection Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Salt/volume depletion. Severe CHF. Renal artery or aortic stenosis. Hypertrophic cardiomyopathy. Monitor for neutropenia in renal or collagen vascular disease. Monitor for hyperkalemia in diabetics. Dialysis. Surgery. Discontinue if laryngeal edema, angioedema, marked elevations of liver enzymes or jaundice occurs. Black patients may have higher risk of angioedema than non-black patients. Elderly. Pregnancy (Cat.C in 1st trimester). Nursing mothers.
Enalaprilat Injection Pharmacokinetics
See Literature
Enalaprilat Injection Interactions
Interactions
Hypotension with diuretics. Hyperkalemia with K+-sparing diuretics or K+ supplements. May increase lithium levels. May be antagonized by NSAIDS.
Enalaprilat Injection Adverse Reactions
Adverse Reactions
Headache, orthostatic hypotension, asthenia, hyperkalemia, renal impairment, nausea, cough; angioedema, liver dysfunction, blood dyscrasias (rare).
Enalaprilat Injection Clinical Trials
See Literature
Enalaprilat Injection Note
Notes
Formerly known under the brand name Vasotec.
Enalaprilat Injection Patient Counseling
See Literature
