EFFIENT Dosage & Rx Info | Uses, Side Effects

Effient Generic Name & Formulations

Legal Class

General Description

Prasugrel 5mg, 10mg; tabs.

Pharmacological Class

P2Y₁₂ platelet inhibitor (thienopyridine).

How Supplied

Tabs—30

Manufacturer

Cosette Pharmaceuticals, Inc.

Generic Availability

YES

Mechanism of Action

Prasugrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y₁₂ class of ADP receptors on platelets.

Effient Indications

Indications

To reduce risk of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with percutaneous coronary intervention (patients with unstable angina (UA) or non-ST-elevation myocardial infarction (NSTEMI); patients with ST-elevation MI (STEMI) when managed with either primary or delayed PCI).

Effient Dosage and Administration

Adult

Loading dose: 60mg once. Maintenance: 10mg once daily. <60kg: consider 5mg once daily. Take with aspirin (75mg–325mg daily).

Children

Not established.

Effient Contraindications

Contraindications

Active pathological bleeding (eg, peptic ulcer, intracranial hemorrhage). Prior TIA or stroke. Do not start if patient likely to undergo urgent CABG.

Effient Boxed Warnings

Boxed Warning

Bleeding risk.

Effient Warnings/Precautions

Warnings/Precautions

Patients ≥75yrs: usually not recommended. Weight <60kg, or CABG or other surgery or trauma, recent or recurrent GI bleeding, severe hepatic dysfunction, moderate-to-severe renal impairment: increased risk of bleeding. Discontinue 7 days before surgery, and if TIA or stroke occurs. Premature discontinuation increases risk for cardiac events (eg, stent thrombosis, MI, death). Pregnancy. Nursing mothers.

Effient Pharmacokinetics

Elimination

Renal (major), fecal.

Effient Interactions

Interactions

Increased bleeding risk with heparin, warfarin, fibrinolytics, chronic NSAID use. Antagonized by opioid agonists (eg, morphine, others); consider using IV anti-platelet agent instead.

Effient Adverse Reactions

Adverse Reactions

Bleeding (may be fatal), hyper- or hypotension, hyperlipidemia, headache, back pain, GI upset, dizziness, cough, chest pain, atrial fibrillation, leukopenia; rare: thrombotic thrombocytopenic purpura, thrombocytopenia, anemia, abnormal hepatic function, hypersensitivity reactions, angioedema.

Effient Clinical Trials

See Literature

Effient Note

Not Applicable

Effient Patient Counseling