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Edecrin Generic Name & Formulations
Legal Class
Rx
General Description
Ethacrynic acid 25mg; scored tabs.
Pharmacological Class
Diuretic (loop).
How Supplied
Tabs—100
Manufacturer
Edecrin Indications
Indications
Treatment of edema when greater diuretic potential is required.
Edecrin Dosage and Administration
Adult
Initially 50–100mg daily; adjust in 25–50mg increments. Usual maintenance: 50–200mg daily or intermittently.
Children
See Contraindications. Initially 25mg; adjust gradually in 25mg increments (see literature).
Edecrin Contraindications
Contraindications
Anuria. Infants. If severe, watery diarrhea occurs, discontinue use and do not restart.
Edecrin Boxed Warnings
Not Applicable
Edecrin Warnings/Precautions
Warnings/Precautions
Renal impairment. Hepatic cirrhosis. Monitor weight, renal function, electrolytes, CO2, BUN. Potassium supplementation may be needed. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Edecrin Pharmacokinetics
See Literature
Edecrin Interactions
Interactions
Digitalis, lithium toxicity. May alter excretion of lithium. Potentiates warfarin. Antagonized by NSAIDs. Orthostatic hypotension with antihypertensives. Ototoxicity with aminoglycosides, other ototoxic agents. May alter glucose tolerance tests.
Edecrin Adverse Reactions
Adverse Reactions
GI upset, anorexia, malaise, abdominal pain, dysphagia, ototoxicity, vertigo, headache, rash, electrolyte imbalance, hyperuricemia, gout, hyperglycemia; rare: agranulocytosis, severe neutropenia, thrombocytopenia.
Edecrin Clinical Trials
See Literature
Edecrin Note
Not Applicable
Edecrin Patient Counseling
See Literature
