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Ecotrin Generic Name & Formulations
Legal Class
OTC
General Description
Aspirin 81mg, 325mg; e-c tabs.
Pharmacological Class
Salicylate.
How Supplied
Tabs 81mg—32, 45, 150, 365; 325mg—125, 300
Manufacturer
Ecotrin Indications
Indications
Arthritic and rheumatic conditions.
Ecotrin Dosage and Administration
Adult
Rheumatoid arthritis, arthritis and pleurisy of SLE: initially 3g daily in divided doses; target plasma salicylate level 150–300mcg/mL. Osteoarthritis: up to 3g/day in divided doses. Spondyloarthropathies: up to 4g/day in divided doses.
Children
JRA: initially 90–130mg/kg per day in divided doses; target plasma salicylate level 150–300mcg/mL.
Ecotrin Contraindications
Contraindications
NSAID allergy. Viral infection in children and teenagers. 3rd trimester pregnancy.
Ecotrin Boxed Warnings
Not Applicable
Ecotrin Warnings/Precautions
Warnings/Precautions
History of asthma or peptic ulcer. Severe hepatic or renal dysfunction. Bleeding disorders. Diabetes. Gout. Pregnancy, nursing mothers: not recommended.
Ecotrin Pharmacokinetics
See Literature
Ecotrin Interactions
Interactions
Potentiates anticoagulants, hypoglycemics, methotrexate, acetazolamide, valproic acid, highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics, uricosurics. Increased bleeding risk with NSAIDs or chronic, heavy alcohol use. NSAIDs increase risk of renal dysfunction.
Ecotrin Adverse Reactions
Adverse Reactions
GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism.
Ecotrin Clinical Trials
See Literature
Ecotrin Note
Not Applicable
Ecotrin Patient Counseling
See Literature
Ecotrin Generic Name & Formulations
Legal Class
OTC
General Description
Aspirin 81mg, 325mg; e-c tabs.
Pharmacological Class
Antiplatelet.
How Supplied
Tabs 81mg—32, 45, 150, 365; 325mg—125, 300
Manufacturer
Generic Availability
YES
Ecotrin Indications
Indications
To reduce combined risk of death and nonfatal stroke after ischemic stroke or TIA. To reduce risk of vascular mortality in suspected acute MI. To reduce combined risk of death and nonfatal MI after MI or unstable angina pectoris. To reduce combined risk of MI and sudden death in chronic stable angina. Revascularization procedures.
Ecotrin Dosage and Administration
Adult
Ischemic stroke and TIA: 50–325mg once daily. Suspected acute MI: 160–162.5mg once daily (start as soon as MI suspected) then for at least 30 days post-MI. Prevention of recurrent MI, unstable angina pectoris, chronic stable angina: 75–325mg once daily. Coronary artery bypass graft: 325mg once daily (start 6 hours after procedure) for 1yr. Percutaneous transluminal coronary angioplasty: 325mg 2hrs before surgery, then 160–325mg once daily. Carotid endarterectomy: 80mg once daily to 650mg twice daily (start before surgery).
Children
Not recommended.
Ecotrin Contraindications
Contraindications
NSAID allergy. Viral infection in children and teenagers. 3rd trimester pregnancy.
Ecotrin Boxed Warnings
Not Applicable
Ecotrin Warnings/Precautions
Warnings/Precautions
History of asthma or peptic ulcer. Severe hepatic or renal dysfunction. Bleeding disorders. Diabetes. Gout. Pregnancy, nursing mothers: not recommended.
Ecotrin Pharmacokinetics
See Literature
Ecotrin Interactions
Interactions
Potentiates anticoagulants, hypoglycemics, methotrexate, acetazolamide, valproic acid, highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics, uricosurics. Increased bleeding risk with NSAIDs or chronic, heavy alcohol use. NSAIDs increase risk of renal dysfunction.
Ecotrin Adverse Reactions
Adverse Reactions
GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism.
Ecotrin Clinical Trials
See Literature
Ecotrin Note
Not Applicable
Ecotrin Patient Counseling
See Literature
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