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Dyrenium Generic Name & Formulations
Legal Class
Rx
General Description
Triamterene 50mg, 100mg; caps.
Pharmacological Class
Diuretic (K+ sparing).
How Supplied
Caps—100
Manufacturer
Dyrenium Indications
Indications
Edema.
Dyrenium Dosage and Administration
Adult
Take after meals. Initially 100mg twice daily; max 300mg daily.
Children
Not recommended.
Dyrenium Contraindications
Contraindications
Concomitant K+ supplements, K+-sparing diuretics, salt substitutes. Hyperkalemia. Anuria. Renal impairment. Severe hepatic disease.
Dyrenium Boxed Warnings
Not Applicable
Dyrenium Warnings/Precautions
Warnings/Precautions
Diabetes. Severely ill. Acidosis predisposition. Electrolyte imbalance. History of renal stones. Gout. Hepatic impairment. Monitor blood, electrolytes, hepatic and renal function frequently. Discontinue if serum potassium >5.5mEq/L or renal values progress. ECG changes or arrhythmias require prompt treatment. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Dyrenium Pharmacokinetics
See Literature
Dyrenium Interactions
Interactions
Avoid K+-sparing diuretics, K+ supplements, and K+ containing salt substitutes. Lithium toxicity. Hyperkalemia more likely with ACE inhibitors. Hyponatremia with sulfonylureas. Acute renal failure with NSAIDs. Adjust antidiabetic medications. Potentiates antihypertensives, nondepolarizing muscle relaxants, anesthetics.
Dyrenium Adverse Reactions
Adverse Reactions
Rarely: anaphylaxis, rash, photosensitivity, hyper- or hypokalemia, azotemia, renal stones, acute interstitial nephritis, jaundice, GI upset, electrolyte disturbances, blood dyscrasias, weakness, fatigue, dizziness, dry mouth.
Dyrenium Clinical Trials
See Literature
Dyrenium Note
Not Applicable
Dyrenium Patient Counseling
See Literature
